Evidence map›Paper›PMID 33278305›Full record

ArticlePsychophysiology2021

Is stressor-evoked cardiovascular reactivity a pathway linking positive and negative emotionality to preclinical cardiovascular disease risk?

Caitlin M DuPont, Aidan G C Wright, Stephen B Manuck, Matthew F Muldoon, J Richard Jennings, Peter J Gianaros

Abstract read
In one paragraph

Article in Psychophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caitlin M DuPontDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8102-5845
Aidan G C WrightDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Stephen B ManuckDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Matthew F MuldoonHeart and Vascular Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
J Richard JenningsDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6988-3348
Peter J GianarosDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2313-5277

Funding

Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSIONR01HL065137 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANUCK, STEPHEN B · 2000 to 2003
$1.5M
NHLBI NIH HHS HL07560NHLBI NIH HHS P01 HL040962NHLBI NIH HHS P01HL040962NHLBI NIH HHS R01 HL065137NHLBI NIH HHS T32 HL007560
6 · The paper itself

Abstract

Stressor-evoked cardiovascular reactivity, trait positive emotionality, and negative emotionality are all associated with cardiovascular disease. It is unknown, however, whether cardiovascular reactivity may constitute a pathway by which trait positive or negative emotionality relates to disease risk. Accordingly, this study modeled the cross-sectional relationships between trait positive and negative emotionality, stressor-evoked cardiovascular reactivity, and severity of a subclinical vascular marker of cardiovascular risk, carotid artery intima-media thickness (CA-IMT). The sample consisted of healthy, midlife adults free from clinical cardiovascular disease (N = 286; ages 30-54; 50% female). Trait positive and negative emotionality were measured by three questionnaires. Heart rate and blood pressure reactivity were assessed across three stressor tasks. CA-IMT was assessed by ultrasonography. Latent factors of positive and negative emotionality, blood pressure reactivity, heart rate reactivity, and CA-IMT were created using structural equation modeling. Greater negative emotionality was marginally associated with more CA-IMT (β = .21; p = .049), but lower blood pressure reactivity (β = -.19; p = .03). However, heightened blood pressure (β = .21; p = .03), but not heart rate reactivity (β = -.05; p = .75), associated with greater CA-IMT. Positive emotionality was uncorrelated with cardiovascular reactivity (blood pressure: β = -.04; p = .61; heart rate: β = .16; p = .11) and CA-IMT (β = .16; p = .07). Although trait negative emotionality associates with a known marker of cardiovascular disease risk, independent of positive emotionality, it is unlikely to occur via a stressor-evoked cardiovascular reactivity pathway.

Indexed as

AdultAtherosclerosisBlood PressureCardiovascular DiseasesCarotid Intima-Media ThicknessCross-Sectional StudiesDisease SusceptibilityEmotionsFemaleHeart RateHumansMaleMiddle AgedPersonalityRiskStress, Psychologicalblood pressurecardiovascularemotionheart ratestress

Identifiers

PMID33278305
PMCPMC8129992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.