Evidence map›Paper›PMID 33278070›Full record

ArticlePhysiological reports2020

Comparison of basal whole-body protein kinetics and muscle protein synthesis between young and older adults.

Katie R Hirsch, David D Church, Il-Young Kim, Sanghee Park, Robert R Wolfe, Arny A Ferrando

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Physiological reports · 2026
    Article
  4. Review
  5. Article
  6. Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Katie R HirschDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-0899-0139
David D ChurchDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0003-4918-5037
Il-Young KimDepartment of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon, South Korea.
Sanghee ParkDepartment of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon, South Korea.
Robert R WolfeDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Arny A FerrandoDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Institute on Aging · USGachon University · KR

Funding

NCATS NIH HHS
6 · The paper itself

Abstract

Significant research has been dedicated to counteracting age-related muscle loss, but underlying mechanisms have not been clearly established. Previous research examining differences in basal protein kinetics between young and older individuals has been limited by a lack of evaluation of protein breakdown and net balance. The aim of this study was to more comprehensively examine differences in basal protein kinetics between younger and older males and females. Basal whole-body protein kinetics and muscle fractional synthetic rate (FSR) from 91 younger (18-38 years; 52% female) and 66 older (51-81 years; 53% female) healthy adults were determined using stable isotope tracer techniques (L-[ring-

Indexed as

AdultAgedAgingBasal MetabolismFemaleHumansMaleMuscle, SkeletalProtein BiosynthesisProteomeSarcopeniaSex FactorsProteomeaginganabolic resistanceprotein metabolismsarcopeniastable isotopes

Identifiers

PMID33278070
PMCPMC7718838
OpenAlexW3110149495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.