Evidence map›Paper›PMID 33278007›Full record

ReviewAdvances in anatomy, embryology, and cell biology2020

Environmental Endocrine Disruptors and Endometriosis.

Jelonia T Rumph, Victoria R Stephens, Anthony E Archibong, Kevin G Osteen, Kaylon L Bruner-Tran

Open access · greenAbstract readReview
In one paragraph

Review in Advances in anatomy, embryology, and cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
135.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women's Health.International journal of environmental research and public health · 2022
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jelonia T RumphDepartment of Microbiology and Immunology, Meharry Medical College, Nashville, TN, USA.
Victoria R StephensWomen's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Anthony E ArchibongDepartment of Microbiology and Immunology, Meharry Medical College, Nashville, TN, USA.
Kevin G OsteenWomen's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Kaylon L Bruner-TranWomen's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA. kaylon.bruner-tran@vanderbilt.edu.
Meharry Medical College · USVanderbilt University · USVA Tennessee Valley Healthcare System · US

Funding

THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007628 · NIGMS · VANDERBILT UNIVERSITY · PI BARNETT, JOEY VICTOR, KAVALALI, EGE T · 1985 to 2022
$11.2M
Dioxin Exposure and the Invasive Pathogenesis of EndometriosisR01ES014942 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRUNER-TRAN, KAYLON L, OSTEEN, KEVIN G · 2006 to 2016
$3.5M
Paternal Toxicant Exposure Impacts Testicular-Placental CrosstalkI01BX002853 · VA · VETERANS HEALTH ADMINISTRATION · PI OSTEEN, KEVIN G · 2016 to 2020
–
BLRD VA I01 BX002853NIEHS NIH HHS R01 ES014942NIEHS NIH HHS T32 ES007028NIGMS NIH HHS R25 GM059994NIGMS NIH HHS T32 GM007628
6 · The paper itself

Abstract

As a consequence of industrialization, thousands of man-made chemicals have been developed with few undergoing rigorous safety assessment prior to commercial use. Ubiquitous exposure to these compounds, many of which act as endocrine-disrupting chemicals (EDCs), has been suggested to be one factor in the increasing incidence of numerous diseases, including endometriosis. Endometriosis, the presence of endometrial glands and stroma outside the uterus, is a common disorder of reproductive-age women. Although a number of population-based studies have suggested that exposure to environmental EDCs may affect a woman's risk of developing this disease, results of epidemiology assessments are often equivocal. The development of endometriosis is, however, a process occurring over time; thus, a single assessment of toxicant body burden cannot definitively be linked to causation of disease. For this reason, numerous investigators have utilized a variety of rodent models to examine the impact of specific EDCs on the development of experimental endometriosis. These studies identified multiple chemicals capable of influencing physiologic processes necessary for the establishment and/or survival of ectopic tissues in rodents, suggesting that these compounds may also be of concern for women. Importantly, these models serve as useful tools to explore strategies that may prevent adverse outcomes following EDC exposure.

Indexed as

AnimalsDisease Models, AnimalEndocrine DisruptorsEndometriosisFemaleHumansEndocrine DisruptorsDevelopmental exposureDioxinEndocrine disruptorsEndometriosisExperimental models

Identifiers

PMID33278007
PMCPMC7978485
OpenAlexW3107844184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.