ArticleJournal of veterinary internal medicine2021
Dynamics of androgens in healthy and hospitalized newborn foals.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Postnatal Dynamics of Circulating Steroid Hormones in Mule and Equine Neonates.Veterinary sciences · 2022Article
- Adrenal Gland Ultrasonographic Measurements and Plasma Hormone Concentrations in Clinically Healthy Newborn Thoroughbred and Standardbred Foals.Animals : an open access journal from MDPI · 2021Article
- Dynamics of androgens in healthy and hospitalized newborn foals.Journal of veterinary internal medicine · 2021Article
- The Systemic Inflammatory Response Syndrome and Predictors of Infection and Mortality in 1068 Critically Ill Newborn Foals.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundInformation on steroids derived from the adrenal glands, gonads, or fetoplacental unit is minimal in newborn foals.
objectiveTo measure androgen concentrations in serum and determine their association with disease severity and outcome in hospitalized foals. ANIMALS: Hospitalized (n = 145) and healthy (n = 80) foals.
methodsProspective, multicenter, cross-sectional study. Foals of ≤3 days of age from 3 hospitals and horse farms were classified as healthy and hospitalized (septic, sick nonseptic, neonatal maladjustment syndrome [NMS]) based on physical exam, medical history, and laboratory findings. Serum androgen and plasma ACTH concentrations were measured with immunoassays. Data were analyzed by nonparametric methods and univariate analysis.
resultsSerum dehydroepiandrosterone (DHEA), androstenedione, testosterone, and dihydrotestosterone (DHT) concentrations were higher upon admission in hospitalized foals (P < .05), were associated with nonsurvival, decreased to 4.9-10.8%, 5.7-31%, and 30.8-62.8% admission values in healthy, SNS, and septic foals, respectively (P < .05), but remained unchanged or increased in nonsurviving foals. ACTH:androgen ratios were higher in septic and NMS foals (P < .05). Foals with decreased androgen clearance were more likely to die (odds ratio > 3; P < .05). CONCLUSIONS AND CLINICAL IMPORTANCE: Similar to glucocorticoids, mineralocorticoids, and progestagens, increased serum concentrations of androgens are associated with disease severity and adverse outcome in hospitalized newborn foals. In healthy foals, androgens decrease over time, however, remain elevated longer in septic and nonsurviving foals. Androgens could play a role in or reflect a response to disorders such as sepsis or NMS in newborn foals.
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Registered trials
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