SynthesisJournal of traumatic stress2021
Posttraumatic Stress Disorder Treatment Effects on Cardiovascular Physiology: A Systematic Review and Agenda for Future Research.
Synthesis in Journal of traumatic stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06429293 (Impact of Cognitive Behavioral Therapy on Neural, Inflammatory, & Autonomic Markers in a Sample With PTSD and Cardiovascular Risk), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Cognitive Behavioral Therapy on Neural, Inflammatory, & Autonomic Markers in a Sample With PTSD and Cardiovascular Risk: Protocol for a Pilot Randomized Controlled Trial
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sexual violence and cardiovascular disease risk: A systematic review and meta-analysis.Maturitas · 2021Pooled it
- Evidence-Based Laboratory Medicine for Cardiovascular Disease Management in Mental Healthcare: A Literature Review.Cureus · 2026Review
- Post-Traumatic Stress Disorder After Acute Cardiovascular Events: Protocol of a Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Article
- PTSD and suPAR: A multicohort investigation of chronic inflammation.Brain, behavior, and immunity · 2026Article
- Neural changes in microgravity: Investigating the effects of aerospace environments.IBRO neuroscience reports · 2025Review
- Biomarkers and Mechanisms of Cardiovascular Susceptibility and Resilience to Post-Traumatic Stress Disorder.Reviews in cardiovascular medicine · 2025Review
- Examining the timing of trauma, PTSD onset, and DNA methylation: A multicohort investigation of candidate CpG sites.Journal of psychiatric research · 2025Article
- Preliminary Results from an RCT Examining the Effects of a Health Behavior Intervention as an Adjunct to Standard Trauma Therapy Among Adults with PTSD.Brain sciences · 2025Article
- Trauma, posttraumatic stress disorder, and incident chronic disease.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- A randomized, 12-month, parallel-group trial testing the effects of a cognitive behavioral healthy lifestyle intervention as an adjunct to standard trauma therapy among adults with PTSD: the I-CHAT study protocol.Frontiers in psychology · 2025Article
- Posttraumatic stress disorder increases thrombosis risk: Evidence from a biobank data set.American journal of hematology · 2024Article
- Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory.Translational psychiatry · 2024Review
- PTSD, Comorbidities, Gender, and Increased Risk of Cardiovascular Disease in a Large Military Cohort.medRxiv : the preprint server for health sciences · 2024Article
- Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.Translational psychiatry · 2024Article
- Impact of cognitive behavioural therapy on neural, inflammatory, & autonomic markers in a sample with PTSD and cardiovascular risk: protocol for a pilot randomised controlled trial.European journal of psychotraumatology · 2024Article
- Effect of PTSD treatment on cardiovascular reactivity during trauma memory recall and correspondence with symptom improvement.European journal of psychotraumatology · 2024Article
- Pilot Findings Indicate a Cognitive Behavioral Healthy Lifestyle Intervention for PTSD Improves Sleep and Physical Activity.Brain sciences · 2023Article
- Dog ownership may promote cardiometabolic health in U.S. military veterans.Scientific reports · 2023Article
- Posttraumatic Stress Disorder as a Consequence of Acute Cardiovascular Disease.Current cardiology reports · 2023Review
- Heart Rate Variability as a Translational Dynamic Biomarker of Altered Autonomic Function in Health and Psychiatric Disease.Biomedicines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is linked to both altered physiological functioning and poorer cardiovascular health outcomes, including an increased risk for cardiovascular disease and cardiovascular-related mortality. An important question is whether interventions for PTSD might ameliorate the risk for poorer health by improving cardiovascular physiological intermediaries. To begin to characterize the literature addressing this question, we conducted a systematic review of empirical studies examining the impact of PTSD interventions on cardiovascular physiological intermediaries, including blood pressure (BP), heart rate (HR), cardiac impedance, and subclinical atherosclerosis. Outcomes included both tonic (i.e., resting) cardiovascular functioning and cardiovascular reactivity (CVR). A total of 44 studies met the inclusion criteria. There was mixed evidence regarding whether PTSD treatment improved tonic cardiovascular functioning. There was stronger evidence that PTSD treatments reduced CVR to trauma-related stressors, particularly for higher-quality studies of cognitive behavioral interventions. No studies examined cardiac impedance or subclinical atherosclerosis. The studies had a high degree of heterogeneity in the populations sampled and interventions tested. Moreover, they generally included small sample sizes and lacked control conditions. Interventions for PTSD may improve cardiovascular physiological outcomes, particularly CVR to trauma cues, although additional methodologically rigorous studies are needed. We outline changes to future research that would improve the literature regarding this important question, including the more frequent use of control groups and larger sample sizes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.