Evidence map›Paper›PMID 33277810›Full record

SynthesisJournal of cellular and molecular medicine2021

Therapy for advanced cholangiocarcinoma: Current knowledge and future potential.

Mingxun Wang, Ziyan Chen, Pengyi Guo, Yi Wang, Gang Chen

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  6. World journal of gastrointestinal surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mingxun WangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Ziyan ChenDepartment of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Pengyi GuoDepartment of Cardiothoracic Surgery, Ningbo Yinzhou NO.2 Hospital, Ningbo, China.
Yi WangDepartment of Epidemiology and Biostatistics, Public Health and Management School, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0001-9278-9827
Gang ChenDepartment of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0001-6067-6959
Wenzhou Medical University · CNNingbo No. 2 Hospital · CN

Funding

National Natural Science Foundation of China 81470868National Natural Science Foundation of China 81703310National Natural Science Foundation of China 81772628
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a biliary epithelial tumour that can emerge at any point in the biliary tree. It is commonly classified based on its anatomical site of development into intrahepatic cholangiocarcinoma (ICC), perihilar cholangiocarcinoma (PCC) and distal cholangiocarcinoma (DCC), each of which is associated with varying patient demographics, molecular characteristics and treatment options. CCA patients have poor overall prognoses and 5-year survival rates. Additionally, CCA is often diagnosed at an advanced stage, with surgical treatment restricted to early-stage disease. Owing to an increase in the incidence of ICC, that of CCA is also on the rise, with a corresponding increase in the associated mortality, particularly in South America and Asia. Therefore, the development of an effective treatment is crucial to improve the survival of CCA patients. We aimed to systematically review the current understanding of advanced CCA treatment and discuss potential effective strategies.

Indexed as

AnimalsCholangiocarcinomaHumansKlatskin TumorModels, BiologicalMutationRadiotherapyReceptor, Fibroblast Growth Factor, Type 2Vascular Endothelial Growth Factor AReceptor, Fibroblast Growth Factor, Type 2Vascular Endothelial Growth Factor Aadvanced tumourcholangiocarcinomacombination therapytumour therapy

Identifiers

PMID33277810
PMCPMC7812297
OpenAlexW3110190529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.