Evidence map›Paper›PMID 33277788›Full record

ArticleGenes, chromosomes & cancer2021

Clonal dynamics in a composite chronic lymphocytic leukemia and hairy cell leukemia-variant.

Maurus Locher, Emina Jukic, Jan-Paul Bohn, Gerold Untergasser, Michael Steurer, Christian Andreas Cramer, Simon Schwendinger, Verena Vogi, Irmgard Verdorfer, Martina Witsch-Baumgartner and 5 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, chromosomes & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Maurus LocherInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-9299-3454
Emina JukicInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Jan-Paul BohnDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Gerold UntergasserDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Michael SteurerDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Christian Andreas CramerCenter for Human Genetics, Philipps University of Marburg, Marburg, Germany.
Simon SchwendingerInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Verena VogiInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Irmgard VerdorferInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Martina Witsch-BaumgartnerInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
David NachbaurDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Eberhard GunsiliusDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Dominik WolfDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Johannes ZschockeInstitute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Normann SteinerDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-9829-1309
Innsbruck Medical University · ATPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Composite lymphoma is the rare simultaneous manifestation of two distinct lymphomas. Chronic lymphocytic leukemia (CLL) has a propensity for occurring in composite lymphomas, a phenomenon that remains to be elucidated. We applied cytogenetics, droplet digital polymerase chain reaction, and massively parallel sequencing to analyze longitudinally a patient with CLL, who 3 years later showed transformation to a hairy cell leukemia-variant (HCL-V). Outgrowth of the IGHV4-34-positive HCL-V clone at the expense of the initially dominant CLL clone with trisomy 12 and MED12 mutation started before CLL-guided treatment and was accompanied by a TP53 mutation, which was already detectable at diagnosis of CLL. Furthermore, deep sequencing of IGH showed a composite lymphoma with presence of both disease components at all analyzed timepoints (down to a minor clone: major clone ratio of ~1:1000). Overall, our analyses showed a disease course that resembled clonal dynamics reported for malignancies with intratumoral heterogeneity and illustrate the utility of deep sequencing of IGH to detect distinct clonal populations at diagnosis, monitor clonal response to therapy, and possibly improve clinical outcomes.

Indexed as

Clone CellsAgedChromosomes, Human, Pair 12Genes, Immunoglobulin Heavy ChainHumansLeukemia, Hairy CellLeukemia, Lymphocytic, Chronic, B-CellMaleNeoplasms, Multiple PrimaryPolymerase Chain ReactionTrisomyWhole Genome SequencingCLLclonal dynamicscomposite lymphomaHCL-VIGHV

Identifiers

PMID33277788
PMCPMC7984250
OpenAlexW3108949842

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.