Evidence map›Paper›PMID 33277787›Full record

ArticleMolecular ecology resources2021

RepeatProfiler: A pipeline for visualization and comparative analysis of repetitive DNA profiles.

Sherif Negm, Anya Greenberg, Amanda M Larracuente, John S Sproul

Open access · greenAbstract read
In one paragraph

Article in Molecular ecology resources, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  3. Satellite DNA evolution in two holocentric species of Edessa true bugs (Hemiptera: Pentatomidae) with unusually high heterochromatin abundance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
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  10. Satellitome Analysis ofInternational journal of molecular sciences · 2024
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  19. Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sherif NegmDepartment of Biology, University of Rochester, Rochester, NY, USA.
Anya GreenbergDepartment of Biology, University of Rochester, Rochester, NY, USA.
Amanda M LarracuenteDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID https://orcid.org/0000-0001-5944-5686
John S SproulDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID https://orcid.org/0000-0002-6747-3537
University of Rochester · US

Funding

The evolutionary and functional genomics of satellite DNAR35GM119515 · NIGMS · UNIVERSITY OF ROCHESTER · PI Amanda Marie Larracuente · 2016 to 2026
$4.0M
Division of Biological Infrastructure DBI-1811930Division of Molecular and Cellular Biosciences MCB-1844693NIGMS NIH HHS R35 GM119515NIH HHS R35GM119515
6 · The paper itself

Abstract

Study of repetitive DNA elements in model organisms highlights the role of repetitive elements (REs) in many processes that drive genome evolution and phenotypic change. Because REs are much more dynamic than single-copy DNA, repetitive sequences can reveal signals of evolutionary history over short time scales that may not be evident in sequences from slower-evolving genomic regions. Many tools for studying REs are directed toward organisms with existing genomic resources, including genome assemblies and repeat libraries. However, signals in repeat variation may prove especially valuable in disentangling evolutionary histories in diverse non-model groups, for which genomic resources are limited. Here, we introduce RepeatProfiler, a tool for generating, visualizing, and comparing repetitive element DNA profiles from low-coverage, short-read sequence data. RepeatProfiler automates the generation and visualization of RE coverage depth profiles (RE profiles) and allows for statistical comparison of profile shape across samples. In addition, RepeatProfiler facilitates comparison of profiles by extracting signal from sequence variants across profiles which can then be analysed as molecular morphological characters using phylogenetic analysis. We validate RepeatProfiler with data sets from ground beetles (Bembidion), flies (Drosophila), and tomatoes (Solanum). We highlight the potential of RE profiles as a high-resolution data source for studies in species delimitation, comparative genomics, and repeat biology.

Indexed as

Data VisualizationDNARepetitive Sequences, Nucleic AcidSoftwareAnimalsColeopteraDrosophilaEvolution, MolecularGenomeGenomicsPhylogenySolanum lycopersicumDNACNV profilescomparative analysisgenome evolutionrepetitive elementsshort-read sequence data

Identifiers

PMID33277787
PMCPMC7954937
OpenAlexW3107419401

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.