ArticleJournal of veterinary internal medicine2021
Diagnostic value of fecal cultures in dogs with chronic diarrhea.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Evaluation of a Novel Compound Probiotic Paste Containing Canine-Derived Vitamin B12-Producing Limosilactobacillus Reuteri.Current microbiology · 2026Article
- Understanding the rationale for metronidazole use in dogs and cats.The Journal of small animal practice · 2025Article
- Impacts of Vincristine and Prednisolone Chemotherapy on the Canine Gut Microbiota in Dogs Undergoing Treatment for Lymphoma.Veterinary and comparative oncology · 2025Article
- Feline enteropathogens and molecular diagnostics: benefits, limitations and clinical applications.Journal of feline medicine and surgery · 2025Review
- Clinical Guidelines for Fecal Microbiota Transplantation in Companion Animals.Advances in small animal care · 2024Article
- Sustainable, greenhouse gas derived fermented protein in canine diets-a pilot study.Frontiers in veterinary science · 2024Article
- Prevalence ofAnimals : an open access journal from MDPI · 2023Article
- Effect of an Enteroprotective Complementary Feed on Faecal Markers of Inflammation and Intestinal Microbiota Composition in Weaning Puppies.Veterinary sciences · 2023Article
- Perspectives and advances in probiotics and the gut microbiome in companion animals.Journal of animal science and technology · 2022Review
- Analysis of the gut microbiome in dogs and cats.Veterinary clinical pathology · 2022Review
- Diagnostic value of fecal cultures in dogs with chronic diarrhea.Journal of veterinary internal medicine · 2021Article
- Longitudinal Survey of Fecal Microbiota in Healthy Dogs Administered a Commercial Probiotic.Frontiers in veterinary science · 2021Article
- Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs.Journal of veterinary internal medicineArticle
- Fecal and Clinical Profiles of Dogs With Chronic Enteropathies Treated With Bile Acid Sequestrants for 5-47 Months: A Retrospective Case Series.Journal of veterinary internal medicineArticle
- Presence of Potential Enteropathogenic Bacteria in Cats and Association With Diarrhea in Multicat Households.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCulture-based assessment of the fecal microbiome using fecal culture profiles frequently is performed in dogs with chronic diarrhea, but the diagnostic value of this approach has not been determined.
objectivesTo compare the reported results of fecal culture profiles and the polymerase chain reaction-based dysbiosis index (DI) between dogs with chronic diarrhea and healthy dogs; to assess interlaboratory variability in bacterial and fungal cultures among 3 veterinary diagnostic laboratories (diagnostic laboratory 1 [L1], diagnostic laboratory 2 [L2], diagnostic laboratory 3 [L3]); and to compare the reported interpretation of culture profiles (normobiosis versus dysbiosis) with those of the DI. ANIMALS: Eighteen dogs with chronic diarrhea (CDG) and 18 healthy control dogs (HG).
methodsIn this prospective, case-control study, fecal samples were submitted to 3 commercial laboratories for fecal culture. The microbiota was assessed using PCR assays. Dogs receiving antimicrobials were excluded.
resultsDysbiosis index was significantly increased in CDG (mean, 0.9; SD, 3.8; 95% confidence interval [CI], -1.0; 2.8) compared to HG (mean, -3.0; SD, 2.8; CI, -4.3; -1.6; P = .0002), whereas cultures from all laboratories failed to detect significant differences (P = .66, .18, and .66, respectively). Hemolytic Escherichia coli was the only potential enteropathogen on culture, but no significant difference was found between CDG and HG. For diagnosis of dysbiosis, culture showed no agreement with DI (L1, κ = -0.21; CI, -0.44; -0.02; L2, κ = -0.33; CI, -0.58; -0.08; L3, κ = -0.25; CI, -0.39; -0.11). Furthermore, variability among the 3 laboratories was high (L1/L2, κ = 0.15; CI, -0.05; 0.35; L1/L3, κ = -0.08; CI, -0.01; -0.16; L2/L3, κ = -0.06; CI, -0.33; -0.20). CONCLUSIONS AND CLINICAL IMPORTANCE: Fecal cultures failed to distinguish between diseased and healthy dogs, and a high level of interlaboratory variation for culture was found.
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