ArticleBJOG : an international journal of obstetrics and gynaecology2021
Aetiological testing compared with syndromic management for sexually transmitted infections in HIV-infected pregnant women in South Africa: a non-randomised prospective cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of antenatalSexually transmitted infections · 2025Trial
- Impact of antenatal screening for Chlamydia and Gonorrhea on pregnancy outcomes in South African women.BMC infectious diseases · 2026Article
- Inequalities in non-HIV sexually transmitted infections in Uganda: a 22-year sex disaggregated trend analysis using WHO Health Equity Assessment Toolkit data.BMC infectious diseases · 2026Article
- Assessing N. gonorrhoeae prevalence and testing capacity for new treatment rollout: a scoping review for Cambodia, Thailand, Vietnam and South Africa.BMC infectious diseases · 2026Article
- Association between partner treatment and repeat sexually transmitted infections positivity in pregnant women in East London, South Africa.Sexually transmitted infections · 2026Article
- Leveraging current capacity to address the high prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis in South Africa: Modelling potential costs and benefits of near point-of-care GeneXpert testing for STIs.PLOS global public health · 2026Article
- Young women's perspectives on a user-friendly self-sampling intervention to improve the diagnosis of sexually transmitted infections in underserved communities in KwaZulu-Natal, South Africa.BMC women's health · 2025Article
- Does a waiting room increase same-day treatment for sexually transmitted infections among pregnant women? A quality improvement study at South African primary healthcare facilities.BMC health services research · 2025Observational
- Antenatal Screening for Sexually Transmitted Infections to Improve Maternal and Newborn Outcomes: An Update From 11 Low- and Middle-Income Countries.Sexually transmitted diseases · 2025Article
- Evaluation of a novel point-of-care lateral flow assay screening for Neisseria gonorrhoeae infection among pregnant women in Zimbabwe.PLOS global public health · 2025Article
- Evaluating Chlamydia trachomatis and Neisseria gonorrhoeae screening and treatment among asymptomatic pregnant women to prevent preterm birth and low birthweight in Gaborone, Botswana: A secondary analysis from a non-randomised, cluster-controlled trial.BJOG : an international journal of obstetrics and gynaecology · 2024Article
- Novel lateral flow assay for point-of-care detection of Neisseria gonorrhoeae infection in syndromic management settings: a cross-sectional performance evaluation.Lancet (London, England) · 2024Article
- Prevalence of sexually transmitted infections (STIs), associations with sociodemographic and behavioural factors, and assessment of the syndromic management of vaginal discharge in women with urogenital complaints in Mozambique.Frontiers in reproductive health · 2024Article
- High incidence of asymptomatic genital tract infections in pregnancy in adolescent girls and young women: need for repeat aetiological screening.Sexually transmitted infections · 2023Article
- A Call to Standardize the Definition and Method of Assessing Women for Vaginal Discharge Syndrome in Pregnancy.Open forum infectious diseases · 2023Article
- The prevalence and risk factors of Trichomonas vaginalis in Wuhan and the Tibetan area, China: a two-center study.Parasitology research · 2023Article
- Detection of metronidazole resistance in Trichomonas vaginalis using uncultured vaginal swabs.Parasitology research · 2022Article
- Article
- Evaluating the diagnosis and treatment of Chlamydia trachomatis and Neisseria gonorrhoeae in pregnant women to prevent adverse neonatal consequences in Gaborone, Botswana: protocol for the Maduo study.BMC infectious diseases · 2022Article
- Significant Associations betweenInfectious diseases in obstetrics and gynecology · 2022Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo measure the frequencies of sexually transmitted infections (STIs) and adverse pregnancy outcomes among women receiving either aetiological testing or syndromic management for STIs.
designNon-randomised prospective cohort study.
settingPrimary healthcare facilities in Tshwane, South Africa. POPULATION: HIV-infected pregnant women attending antenatal care services.
methodsParticipants were enrolled to receive aetiological testing using Xpert® CT/NG and Xpert® TV assays or standard syndromic management. Outcome data were collected at the postnatal care visit (≤30 days from delivery) and from maternity records. Enrolment gestational age-adjusted relative risk (aRR) was calculated.
main outcome measuresSTI prevalence at postnatal visit, and frequency of adverse pregnancy outcomes (preterm birth, low birthweight).
resultsWe enrolled 841 women. The prevalence of any STI at baseline was 40%; Chlamydia trachomatis 30%, Neisseria gonorrhoeae 5.6%, Trichomonas vaginalis 20%. The prevalence of STIs at postnatal care was lower among those receiving aetiological testing compared with those receiving syndromic management (14% versus 23%; aRR 0.61; 95% CI 0.35-1.05). No difference was observed between study groups for frequency of preterm birth (23% versus 23%; aRR 1.2, 95% CI 0.81-1.8) and low birth weight (15% versus 13%; aRR 1.1, 95% CI 0.66-1.7).
conclusionsAetiological testing provides an effective intervention to reduce the high burden of STIs in pregnant women in South Africa; however, the optimal implementation strategy remains to be determined. TWEETABLE ABSTRACT: Aetiological testing effectively reduces the burden of sexually transmitted infections in pregnancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.