Evidence map›Paper›PMID 33277750›Full record

ArticleCancer science2021

α-Emitting cancer therapy using

Kazuko Kaneda-Nakashima, ZiJian Zhang, Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Tadashi Watabe, Yoshikatsu Kanai, Kazuhiro Ooe, Atsushi Toyoshima, Yoshifumi Shirakami and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. L-3-[International journal of molecular sciences · 2025
    Pooled it
  2. Article
  3. Review
  4. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  5. LAT1-Targeted Alpha Therapy UsingInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Therapeutic efficacy ofChemical science · 2023
    Article
  12. Article
  13. Article
  14. Targeted α-therapy using astatine (European journal of nuclear medicine and molecular imaging · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Comparison of the Therapeutic Effects of [International journal of molecular sciences · 2022
    Article
  19. Review
  20. Protection from contamination byEJNMMI physics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Kazuko Kaneda-NakashimaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-6657-5059
ZiJian ZhangMS-CORE, PRC, Graduate School of Science, Osaka University, Osaka, Japan.
Yoshiyuki ManabeDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-5515-3923
Atsushi ShimoyamaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0003-1910-0450
Kazuya KabayamaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-7583-5454
Tadashi WatabeDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-8658-2395
Yoshikatsu KanaiDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-8126-286X
Kazuhiro OoeDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-8560-027X
Atsushi ToyoshimaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.
Yoshifumi ShirakamiDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.
Takashi YoshimuraDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-9216-9043
Mitsuhiro FukudaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.
Jun HatazawaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.
Takashi NakanoDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.
Koichi FukaseDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-8844-0710
Atsushi ShinoharaDivision of Science, Institute for Radiation Sciences, Osaka University, Osaka, Japan.
Osaka City University · JPOsaka Health Science University · JP

Funding

KAKENHI 15H05836KAKENHI (C) JPMJOP1721QiSS program of the OPERA JPMJOP1721Supply Platform of Short-lived Radioisotopes 16H06278
6 · The paper itself

Abstract

α-Methyl-l-tyrosine (AMT) has a high affinity for the cancer-specific l-type amino acid transporter 1 (LAT1). Therefore, we established an anti-cancer therapy, with

Indexed as

alpha-MethyltyrosineAlpha ParticlesAnimalsAstatineCell Line, TumorDisease Models, AnimalDNA Breaks, Double-StrandedDrug CarriersFeasibility StudiesFemaleHEK293 CellsHumansLarge Neutral Amino Acid-Transporter 1MaleMiceNeoplasmsalpha-MethyltyrosineAstatineAstatine-211Drug CarriersLarge Neutral Amino Acid-Transporter 1SLC7A5 protein, humanSlc7a5 protein, mouseamino acidanti-cancer drugastatine-211large neutral amino acid transporter 1nuclear medicine

Identifiers

PMID33277750
PMCPMC7935802
OpenAlexW3109853059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.