ArticleCommunications biology2020
Individual variability in functional connectivity architecture of the mouse brain.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- A systematic review of the relationship between magnetic resonance imaging based resting-state and structural networks in the rodent brain.Frontiers in neuroscience · 2023Pooled it
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in Mice.bioRxiv : the preprint server for biology · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The ANTsX ecosystem for mapping the mouse brain.Nature communications · 2025Article
- Precision functional mapping reveals less inter-individual variability in the child vs. adult human brain.bioRxiv : the preprint server for biology · 2025Article
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain.Molecular psychiatry · 2025Article
- Multimodal identification of the mouse brain using simultaneous CaCommunications biology · 2025Article
- Modular strategies for spatial mapping of diverse cell type data of the mouse brain.Research square · 2025Article
- IFN-γ reprograms cardiac microvascular endothelial cells to mediate doxorubicin transport and influences the sensitivity of mice to doxorubicin-induced cardiotoxicity.Experimental & molecular medicine · 2025Article
- Awake rodent fMRI: Gradient-echo echo planar imaging versus compressed-sensing fast low-angle shot.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantifying individual variability in neural control circuit regulation using single-subject fMRI.Computational brain & behavior · 2023Article
- To be and not to be: wide-field Ca2+ imaging reveals neocortical functional segmentation combines stability and flexibility.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective.International journal of molecular sciences · 2023Review
- Individual differences in the language task-evoked and resting-state functional networks.Frontiers in human neuroscience · 2023Article
- Mapping Inter-individual Functional Connectivity Variability in TMS Targets for Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Applications in Awake Animal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years precision fMRI has emerged in human brain research, demonstrating characterization of individual differences in brain organization. However, mechanistic investigations to the sources of individual variability are limited in humans and thus require animal models. Here, we used resting-state fMRI in awake mice to quantify the contribution of individual variation to the functional architecture of the mouse cortex. We found that the mouse connectome is also characterized by stable individual features that support connectivity-based identification. Unlike in humans, we found that individual variation is homogeneously distributed in sensory and association networks. Finally, connectome-based predictive modeling of motor behavior in the rotarod task revealed that individual variation in functional connectivity explained behavioral variability. Collectively, these results establish the feasibility of precision fMRI in mice and lay the foundation for future mechanistic investigations of individual brain organization and pre-clinical studies of brain disorders in the context of personalized medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.