ArticleScientific reports2020
Bacterial diversity and functional analysis of severe early childhood caries and recurrence in India.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unlocking the potential of probiotic administration in caries management: a systematic review.BMC oral health · 2024Pooled it
- Trial
- Comparative analysis of the dental plaque metabolome in tooth stain and caries within primary dentition.BMC oral health · 2026Article
- Construction of caries risk assessment scale and oral microecology analysis of adolescents with fixed orthodontic treatment.BMC oral health · 2026Article
- Investigating oral microbiome profiles of children with cleft lip and palate in different states of caries.Journal of oral microbiology · 2026Article
- Co-infection with CbpJournal of oral microbiology · 2026Article
- Metabolic profiling of severe early childhood caries and black stain: pathway and biomarker discovery in 3-6-year-olds.Frontiers in molecular biosciences · 2026Article
- The Impact of Human Salivary Amylase Gene Copy Number and Starch on Oral Biofilms.Microorganisms · 2025Article
- Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- The link between inflammatory/ SCFA profiles and oral/gut microbiome: an observational study in patients with ST-segment elevation myocardial infarction.Current research in microbial sciences · 2025Article
- Microbiome in Early Childhood Caries: Caries Severity-Dependent Insights.Caries research · 2025Article
- Metagenomic Analysis of the Buccal Microbiome by Nanopore Sequencing Reveals Structural Differences in the Microbiome of a Patient with Molar Incisor Hypomineralization (MIH) Compared to a Healthy Child-Case Study.International journal of molecular sciences · 2024Article
- Article
- Article
- Saliva sampling method influences oral microbiome composition and taxa distribution associated with oral diseases.PloS one · 2024Article
- Plaque Microbiome in Caries-Active and Caries-Free Teeth by Dentition.JDR clinical and translational research · 2024Article
- Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries.BMC oral health · 2023Article
- Salivary microbiome and metabolome analysis of severe early childhood caries.BMC oral health · 2023Article
- Article
- Oral Microbiome and Dental Caries Development.Dentistry journal · 2022Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries is the most prevalent oral disease affecting nearly 70% of children in India and elsewhere. Micro-ecological niche based acidification due to dysbiosis in oral microbiome are crucial for caries onset and progression. Here we report the tooth bacteriome diversity compared in Indian children with caries free (CF), severe early childhood caries (SC) and recurrent caries (RC). High quality V3-V4 amplicon sequencing revealed that SC exhibited high bacterial diversity with unique combination and interrelationship. Gracillibacteria_GN02 and TM7 were unique in CF and SC respectively, while Bacteroidetes, Fusobacteria were significantly high in RC. Interestingly, we found Streptococcus oralis subsp. tigurinus clade 071 in all groups with significant abundance in SC and RC. Positive correlation between low and high abundant bacteria as well as with TCS, PTS and ABC transporters were seen from co-occurrence network analysis. This could lead to persistence of SC niche resulting in RC. Comparative in vitro assessment of biofilm formation showed that the standard culture of S. oralis and its phylogenetically similar clinical isolates showed profound biofilm formation and augmented the growth and enhanced biofilm formation in S. mutans in both dual and multispecies cultures.
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