ArticleNPJ schizophrenia2020
Personalized estimates of morphometric similarity in bipolar disorder and schizophrenia.
Article in NPJ schizophrenia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.Translational psychiatry · 2026Article
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.Molecular psychiatry · 2026Article
- Structural brain variability in recent-onset and chronic schizophrenia: evidence from person-based similarity index analysis.Acta neuropsychiatrica · 2025Article
- Individual-level brain phenotypes in first-episode mania: normative modelling of brain morphometry and brainAGE.BJPsych open · 2025Article
- Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum.Schizophrenia (Heidelberg, Germany) · 2024Article
- Multimodal Neuroimaging Summary Scores as Neurobiological Markers of Psychosis.Schizophrenia bulletin · 2024Article
- Application of hyperalignment to resting state data in individuals with psychosis reveals systematic changes in functional networks and identifies distinct clinical subgroups.Aperture neuro · 2024Article
- Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance.Molecular autism · 2023Article
- Aberrant neurophysiological signaling associated with speech impairments in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders.NeuroImage. Clinical · 2023Article
- Cumulative Impact of Morphometric Features in Schizophrenia in Two Independent Samples.Schizophrenia bulletin open · 2023Article
- Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis.Translational psychiatry · 2022Article
- Person-Based Similarity Index for Cognition and Its Neural Correlates in Late Adulthood: Implications for Cognitive Reserve.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.Frontiers in aging neuroscience · 2022Article
- Personalized Estimates of Brain Structural Variability in Individuals With Early Psychosis.Schizophrenia bulletin · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Bipolar disorder and schizophrenia are associated with brain morphometry alterations. This study investigates inter-individual variability in brain structural profiles, both within diagnostic groups and between patients and healthy individuals. Brain morphometric measures from three independent samples of patients with schizophrenia (n = 168), bipolar disorder (n = 122), and healthy individuals (n = 180) were modeled as single vectors to generated individualized profiles of subcortical volumes and regional cortical thickness. These profiles were then used to compute a person-based similarity index (PBSI) for subcortical volumes and for regional cortical thickness, to quantify the within-group similarity of the morphometric profile of each individual to that of the other participants in the same diagnostic group. There was no effect of diagnosis on the PBSI for subcortical volumes. In contrast, compared to healthy individuals, the PBSI for cortical thickness was lower in patients with schizophrenia (effect size = 0.4, p ≤ 0.0002), but not in patients with bipolar disorder. The results were robust and reproducible across samples. We conclude that disease mechanisms for these disorders produce modest inter-individual variations in brain morphometry that should be considered in future studies attempting to cluster patients in subgroups.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.