Evidence map›Paper›PMID 33277402›Full record

Observational studyRMD open2020

Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT.

Nienke J Kleinrensink, Wouter Foppen, Iris Ten Katen, Pieternella H van der Veen, Bo de Klerk, Suzanne C E Diepstraten, Timothy R D J Radstake, Floris P J G Lafeber, Pim A de Jong, Emmerik F A Leijten

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in RMD open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Imaging update in spondyloarthropathy.Journal of clinical orthopaedics and trauma · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nienke J KleinrensinkDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, Netherlands N.J.Kleinrensink-2@umcutrecht.nl.ORCID 0000-0003-4010-6179
Wouter FoppenDepartment of Radiology, UMC Utrecht, Utrecht, Netherlands.ORCID 0000-0003-4970-8555
Iris Ten KatenDepartment of Radiology, UMC Utrecht, Utrecht, Netherlands.
Pieternella H van der VeenDepartment of Radiology, UMC Utrecht, Utrecht, Netherlands.
Bo de KlerkDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, Netherlands.
Suzanne C E DiepstratenDepartment of Radiology, UMC Utrecht, Utrecht, Netherlands.
Timothy R D J RadstakeDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, Netherlands.
Floris P J G LafeberDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, Netherlands.
Pim A de JongDepartment of Radiology, UMC Utrecht, Utrecht, Netherlands.
Emmerik F A LeijtenDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, Netherlands.
University Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the Heel Enthesitis MRI Scoring model (HEMRIS) with clinical and PET/CT outcomes in patients with cutaneous psoriasis (Pso), psoriatic arthritis (PsA) or ankylosing spondylitis (AS).

methodsThis prospective, observational study included 38 patients with Pso, PsA and AS. Patients were included regardless of presence or absence of clinical heel enthesitis. MRI-scans of both ankles and a whole-body

resultsIn total, 146 entheses were scored according to the HEMRIS and clinically assessed for enthesitis (6 entheses were clinically affected). In Achilles tendons with clinical enthesitis, the HEMRIS structural damage score was significantly higher, compared to Achilles tendons without clinical enthesitis (respective median scores 1.0 and 0.5; p=0.04). In clinically unaffected entheses, HEMRIS abnormalities occurred in 44/70 (63%) of Achilles tendons and in 23/70 (33%) of plantar fascia. At the Achilles tendon, local metabolic activity measured on PET/CT was weakly associated with the structural (r

conclusionThis study revealed a high prevalence of subclinical HEMRIS abnormalities and discrepancy between HEMRIS and clinical and PET/CT findings. This may suggest that the HEMRIS is a sensitive method for detection of inflammatory and structural disease of enthesitis at the Achilles tendon and plantar fascia, although the clinical significance of these MRI findings remains to be determined in longitudinal studies.

Indexed as

EnthesopathyHeelPositron Emission Tomography Computed TomographyAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesAnkylosingArthritisMagnetic Resonance ImagingPsoriaticSpondylitis

Identifiers

PMID33277402
PMCPMC7856158
OpenAlexW3108751965

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.