Evidence map›Paper›PMID 33277375›Full record

ArticleScience immunology2020

BATF regulates innate lymphoid cell hematopoiesis and homeostasis.

Qingyang Liu, Myung H Kim, Leon Friesen, Chang H Kim

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  13. Review
  14. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  15. Transcriptional control of ILC identity.Frontiers in immunology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Antiviral Activities of Group I Innate Lymphoid Cells.Journal of molecular biology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Qingyang LiuDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1923-4208
Myung H KimLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-8444-6952
Leon FriesenDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Chang H KimDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. chhkim@umich.edu.ORCID 0000-0003-4618-9139
University of Michigan · USPurdue University West Lafayette · US

Funding

Homing of Functionally Distinct ILC SubsetsR01AI121302 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CHANG H · 2016 to 2020
$1.9M
FoxP3+ T cells of mucosal tissuesR01AI074745 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2008 to 2012
$1.7M
Migration and function of Th17 cells in the gutR01AI080769 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2010 to 2013
$1.3M
Regulation of the development of dendritic cells in barrier tissues by retinoid gradientsR21AI148898 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CHANG H · 2020 to 2021
$414k
NIAID NIH HHS R01 AI074745NIAID NIH HHS R01 AI080769NIAID NIH HHS R01 AI121302NIAID NIH HHS R21 AI148898
6 · The paper itself

Abstract

Early hematopoietic progenitors undergo sophisticated developmental processes to become committed innate lymphoid cell (ILC) progenitors and ultimately mature ILC subsets in the periphery. Basic leucine zipper ATF-like transcription factor (Batf) plays important roles in lymphocyte biology. We report here that Batf regulates the production of bone marrow ILC progenitors and maintenance of peripheral ILCs. The expression of Batf is induced during ILC development at the α-lymphoid progenitor stage in response to the cytokine IL-7. As a potential mechanism, up-regulated Batf binds and activates transcription of the

Indexed as

HomeostasisImmunity, InnateAnimalsBasic-Leucine Zipper Transcription FactorsCytokinesGene Expression RegulationGene Knockdown TechniquesHematopoiesisImmunophenotypingLymphocyte SubsetsLymphoid Progenitor CellsMiceMice, KnockoutOrgan SpecificitySignal TransductionBasic-Leucine Zipper Transcription FactorsBatf protein, mouseCytokines

Identifiers

PMID33277375
PMCPMC8375455
OpenAlexW3107632603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.