Evidence map›Paper›PMID 33277275›Full record

ArticleBMJ open2020

Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol.

Mandy Xian Hu, Christina Palantza, Kim Setkowski, Renske Gilissen, Eirini Karyotaki, Pim Cuijpers, Heleen Riper, Derek de Beurs, Chani Nuij, Helen Christensen and 7 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Innovations to improve outcomes and uptake of psychotherapies for mental disorders: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Mandy Xian HuGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands x.hu@113.nl.ORCID 0000-0002-4496-8772
Christina PalantzaGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Kim Setkowski113 Zelfmoordpreventie, Amsterdam, The Netherlands.
Renske Gilissen113 Zelfmoordpreventie, Amsterdam, The Netherlands.
Eirini KaryotakiDepartment of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Pim CuijpersDepartment of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5497-2743
Heleen RiperGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Derek de BeursDepartment of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Chani NuijDepartment of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Helen ChristensenBlack Dog Institute, University of New South Wales, Sydneyali, New South Wales, Australia.
Alison CalearCentre for Mental Health Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Aliza Werner-SeidlerBlack Dog Institute, University of New South Wales, Sydneyali, New South Wales, Australia.ORCID 0000-0002-9046-6159
Adriaan HoogendoornGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Anton van BalkomGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Merijn EikelenboomGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Jan SmitGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
Wouter van BallegooijenGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
GGZ inGeest · NLVrije Universiteit Amsterdam · NLBlack Dog Institute · AUAristotle University of Thessaloniki · GRAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPsychotherapy may reduce suicidal thoughts and behaviour, but its effectiveness is not well examined. Furthermore, conventional meta-analyses are unable to test possible effects of moderators affecting this relationship. This protocol outlines the building of a comprehensive database of the literature in this research field. In addition, we will conduct an individual patient data meta-analysis (IPD-MA) to establish the effectiveness of psychotherapy in reducing suicidality, and to examine which factors moderate the efficacy of these interventions. METHODS AND ANALYSIS: To build a comprehensive database, randomised controlled trials examining the effect of any psychotherapy targeting any psychiatric disorder on suicidal thoughts or behaviour will be identified by running a systematic search in PubMed, Embase, PsycINFO, Web of Science, Scopus and The Cochrane Central Register of Controlled Trials from data inception to 12 August 2019. For the IPD-MA, we will focus on adult outpatients with suicidal ideation or behaviour. In addition, as a comparison group we will focus on a control group (waiting-list, care as usual or placebo). A 1-stage IPD-MA will be used to determine the effectiveness of psychotherapy on suicidal ideation, suicide attempts and/or suicide deaths, and to investigate potential patient-related and intervention-related moderators. Subgroup and sensitivity analyses will be conducted to test the robustness of the findings. Additionally, a conventional MA will be conducted to determine the differences between studies that provided IPD and those that did not. IPD-MA may determine the effectiveness of psychotherapy in reducing suicidality and provide insights into the moderating factors influencing the efficacy of psychotherapy. Answering these questions will inform mental healthcare practitioners about optimal treatments for different groups of individuals with suicidal ideation and/or behaviour and consequently help to reduce suicide risk. ETHICS AND DISSEMINATION: An ethical approval is not required for this study. The results will be published in a peer-review journal. PROSPERO REGISTRATION NUMBER: CRD42020140573.

Indexed as

PsychotherapySuicidal IdeationDatabases, FactualHumansMeta-Analysis as TopicRandomized Controlled Trials as Topicindividual patient datameta-analysisprotocolpsychotherapyrandomized controlled trialSuicide prevention

Identifiers

PMID33277275
PMCPMC7722389
OpenAlexW3108960653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.