ArticleScience advances2020
Enabling near-atomic-scale analysis of frozen water.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 citations in OpenAlex.
- Thermomechanics of Picoliter Liquids Encapsulated in Metal Microarchitectures.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A workflow for correlativeNanoscale horizons · 2025Article
- Scalable substrate development for aqueous sample preparation for atom probe tomography.Journal of microscopy · 2025Article
- The Fate of Water in Hydrogen-Based Iron Oxide Reduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Electron microscope loading and in situ nanoindentation of water ice at cryogenic temperatures.PloS one · 2023Article
- Nanoscale analysis of frozen honey by atom probe tomography.Scientific reports · 2022Article
- Understanding the Degradation of a Model Si Anode in a Li-Ion Battery at the Atomic Scale.The journal of physical chemistry letters · 2022Article
- Atomic-scale 3D imaging of individual dopant atoms in an oxide semiconductor.Nature communications · 2022Article
- 3D sub-nanometer analysis of glucose in an aqueous solution by cryo-atom probe tomography.Scientific reports · 2021Article
- Atom probe tomography.Nature reviews. Methods primers · 2021Article
- Hydrogen and deuterium charging of lifted-out specimens for atom probe tomography.Open research Europe · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmission electron microscopy went through a revolution enabling routine cryo-imaging of biological and (bio)chemical systems, in liquid form. Yet, these approaches typically lack advanced analytical capabilities. Here, we used atom probe tomography to analyze frozen liquids in three dimensions with subnanometer resolution. We introduce a specimen preparation strategy using nanoporous gold. We report data on 2- to 3-μm-thick layers of ice formed from both high-purity deuterated water and a solution of 50 mM NaCl in high-purity deuterated water. The analysis of the gold-ice interface reveals a substantial increase in the solute concentrations across the interface. We explore a range of experimental parameters to show that atom probe analyses of bulk aqueous specimens come with their own challenges and discuss physical processes that produce the observed phenomena. Our study demonstrates the viability of using frozen water as a carrier for near-atomic-scale analysis of objects in solution by atom probe tomography.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.