ReviewNutrition (Burbank, Los Angeles County, Calif.)2021
Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic.
Review in Nutrition (Burbank, Los Angeles County, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Agronomic biofortification of food crops: An emerging opportunity for global food and nutritional security.Frontiers in plant science · 2022Pooled it
- Micronutrients Deficiency, Supplementation and Novel Coronavirus Infections-A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Article
- Review
- The close association of micronutrients with COVID-19.Heliyon · 2024Article
- Changes in menstrual cycles among Iranian women during the COVID-19 pandemic: A cross-sectional study.International journal of reproductive biomedicine · 2024Article
- Micronutrients Importance in Cancer Prevention-Vitamins.Cancer treatment and research · 2024Review
- Review
- Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.Molecules (Basel, Switzerland) · 2023Review
- Update on the effectiveness of COVID-19 vaccines on different variants of SARS-CoV-2.International immunopharmacology · 2023Review
- Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties.Antioxidants (Basel, Switzerland) · 2023Review
- COVID-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation.Cellular and molecular neurobiology · 2023Review
- Modifiable contributing factors to COVID-19: A comprehensive review.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023Review
- Mediterranean diet and the risk of COVID-19 in the 'Seguimiento Universidad de Navarra' cohort.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Low serum levels of zinc and 25-hydroxyvitmain D as potential risk factors for COVID-19 susceptibility: a pilot case-control study.European journal of clinical nutrition · 2022Article
- The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients.Infection · 2022Article
- Spotlight on therapeutic efficiency of mesenchymal stem cells in viral infections with a focus on COVID-19.Stem cell research & therapy · 2022Review
- Healthy Immunity on Preventive Medicine for Combating COVID-19.Nutrients · 2022Review
- Contributing factors common to COVID‑19 and gastrointestinal cancer.Oncology reports · 2022Review
- Invasive plants as biosorbents for environmental remediation: a review.Environmental chemistry letters · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preliminary studies indicate that a robust immune response across different cell types is crucial in recovery from coronavirus disease 2019 (COVID-19). An enormous number of investigations point to the vital importance of various micronutrients in the interactions between the host immune system and viruses, including COVID-19. There are complex and multifaceted links among micronutrient status, the host immune response, and the virulence of pathogenic viruses. Micronutrients play a critical role in the coordinated recruitment of innate and adaptive immune responses to viral infections, particularly in the regulation of pro- and anti-inflammatory host responses. Furthermore, inadequate amounts of micronutrients not only weaken the immune system in combating viral infections, but also contribute to the emergence of more virulent strains via alterations of the genetic makeup of the viral genome. The aim of this study was to evaluate the evidence that suggests the contribution of micronutrients in the spread as well as the morbidity and mortality of COVID-19. Both the presence of micronutrient deficiencies among infected individuals and the effect of micronutrient supplementation on the immune responses and overall outcome of the disease could be of great interest when weighing the use of micronutrients in the prevention and treatment of COVID-19 infection. These investigations could be of great value in dealing with future viral epidemics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.