Evidence map›Paper›PMID 33276704›Full record

GuidelineThyroid : official journal of the American Thyroid Association2021

Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.

Jacqueline Jonklaas, Antonio C Bianco, Anne R Cappola, Francesco S Celi, Eric Fliers, Heike Heuer, Elizabeth A McAninch, Lars C Moeller, Birte Nygaard, Anna M Sawka and 2 more

Open access · greenAbstract readConsensus StatementPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Pooled it
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  9. EndoBridge 2025: pearls and highlights.Hormones (Athens, Greece) · 2026
    Review
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  20. Why the science on TNature reviews. Endocrinology · 2025
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 6 countries.

Jacqueline JonklaasDivision of Endocrinology, Georgetown University, Washington, District of Columbia, USA.
Antonio C BiancoSection of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, Illinois, USA.
Anne R CappolaDivision of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Francesco S CeliDivision of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA.
Eric FliersDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, Netherlands.
Heike HeuerDepartment of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany.
Elizabeth A McAninchDivision of Endocrinology, Rush University, Chicago, Illinois, USA.
Lars C MoellerDepartment of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany.
Birte NygaardCenter for Endocrinology and Metabolism, Department Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark.
Anna M SawkaDivision of Endocrinology, University Health Network and University of Toronto, Toronto, Canada.
Torquil WattDepartment of Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Colin M DayanThyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom.
University of Duisburg-Essen · DEAmsterdam University Medical Centers · NLCardiff University · GBCopenhagen University Hospital · DKGeorgetown University · USHerlev Hospital · DKRush University · USUniversity Health Network · CAUniversity of Chicago · USUniversity of Pennsylvania · USVirginia Commonwealth University · US

Funding

Midcareer Investigator Award in Patient-Oriented Research in AgingK24AG042765 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2013 to 2024
$1.7M
Capturing the Impact of Craniofacial Damage after Radioiodine TherapyR01DE025822 · NIDCR · GEORGETOWN UNIVERSITY · PI GRAVES, KRISTI D., JONKLAAS, JACQUELINE · 2016 to 2020
$1.3M
Energy Metabolism in Thyroidectomized PatientsR21DK122310 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI STAMATOULI, ANGELIKI MARIA · 2020 to 2021
$384k
NIA NIH HHS K24 AG042765NIDCR NIH HHS R01 DE025822NIDDK NIH HHS R21 DK122310
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ConsensusDrug CombinationsEvidence-Based MedicineHumansHypothyroidismThyroxineTreatment OutcomeTriiodothyronineDrug CombinationsThyroxineTriiodothyronineclinical trialcombination therapyhypothyroidismlevothyroxineliothyroninepatient-reported outcomes

Identifiers

PMID33276704
PMCPMC8035928
OpenAlexW3106666427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.