Evidence map›Paper›PMID 33276584›Full record

ArticleCells2020

Elovl2 Is Required for Robust Visual Function in Zebrafish.

Manish Dasyani, Fangyuan Gao, Qianlan Xu, Donald Van Fossan, Ellis Zhang, Antonio F M Pinto, Alan Saghatelian, Dorota Skowronska-Krawczyk, Daniel L Chao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Manish DasyaniViterbi Family Department of Ophthalmology, Shiley Eye Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Fangyuan GaoDepartment of Biophysics and Physiology, Center for Translational Vision Research, Gavin Hebert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92617, USA.
Qianlan XuViterbi Family Department of Ophthalmology, Shiley Eye Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Donald Van FossanViterbi Family Department of Ophthalmology, Shiley Eye Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Ellis ZhangViterbi Family Department of Ophthalmology, Shiley Eye Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Antonio F M PintoThe Salk Institute for Biological Studies, Clayton Foundation Laboratories for Peptide Biology, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA.ORCID 0000-0002-1573-8011
Alan SaghatelianThe Salk Institute for Biological Studies, Clayton Foundation Laboratories for Peptide Biology, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
Dorota Skowronska-KrawczykViterbi Family Department of Ophthalmology, Shiley Eye Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5758-4225
Daniel L ChaoViterbi Family Department of Ophthalmology, Shiley Eye Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
University of California San Diego · USUniversity of California, Irvine · USSalk Institute for Biological Studies · US

Funding

Dissecting the role of ELOVL2 in Drusen Biogenesis and Age Related Macular DegenerationK08EY030510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAO, DANIEL L · 2019 to 2020
$482k
NEI NIH HHS K08 EY030510
6 · The paper itself

Abstract

Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) play critical roles in membrane stability and cell signaling within the retina. ELOVL2 (Elongation of Very Long Chain Fatty Acids-Like 2), an elongase involved in the synthesis of long chain polyunsaturated fatty acids (LC-PUFAs), has recently been implicated in regulating aging in the mammalian retina. In this work, we characterize the expression and function of

Indexed as

Gene Expression Regulation, DevelopmentalVision, OcularAcetyltransferasesAnimalsDocosahexaenoic AcidsFatty Acids, UnsaturatedIn Situ HybridizationLipidomicsLipidsNeurogliaPhenotypeRetinaZebrafishZebrafish ProteinsAcetyltransferasesDocosahexaenoic AcidsElovl2 protein, zebrafishFatty Acids, UnsaturatedLipidsZebrafish ProteinsELOVL2 (Elongation of Very Long Chain Fatty Acids-Like 2)Muller gliapolyunsaturated fatty acidsvision

Identifiers

PMID33276584
PMCPMC7761535
OpenAlexW3110447249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.