Evidence map›Paper›PMID 33276545›Full record

ReviewMolecules (Basel, Switzerland)2020

Promising Lead Compounds in the Development of Potential Clinical Drug Candidate for Drug-Resistant Tuberculosis.

Saad Alghamdi, Shaheed Ur Rehman, Nashwa Talaat Shesha, Hani Faidah, Muhammad Khurram, Sabi Ur Rehman

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saad AlghamdiLaboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca 24321, Saudi Arabia.ORCID 0000-0003-4532-9128
Shaheed Ur RehmanDepartment of Pharmacy, Abasyn University Peshawar, Khyber Pakhtunkhwa 25000, Pakistan.
Nashwa Talaat SheshaRegional Laboratory, Directorate of Health Affairs Makkah, Mecca 24321, Saudi Arabia.
Hani FaidahMicrobiology Department, Faculty of Medicine, Umm Al-Qura University, Mecca 24321, Saudi Arabia.
Muhammad KhurramDepartment of Pharmacy, Abasyn University Peshawar, Khyber Pakhtunkhwa 25000, Pakistan.ORCID 0000-0002-8375-8532
Sabi Ur RehmanDepartment of Pharmacy, Abasyn University Peshawar, Khyber Pakhtunkhwa 25000, Pakistan.ORCID 0000-0002-0880-0358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities with HIV and diabetes are present. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. As a better understanding of tuberculosis, microanatomy has discovered an extended range of new promising antitubercular targets and diagnostic biomarkers. However, there are still no new approved antitubercular drugs of routine therapy for several decades, except for bedaquiline, delamanid, and pretomanid approved tentatively. Despite this, innovative methods are also urgently needed to find potential new antitubercular drug candidates, which potentially decimate both latent state and active state

Indexed as

Drug DesignAnimalsAntitubercular AgentsCoumarinsHumansIsoniazidMycobacterium tuberculosisPeptides, CyclicPharmaceutical PreparationsPore Forming Cytotoxic ProteinsTuberculosis, Multidrug-ResistantAntitubercular AgentscoumarinCoumarinsgriselimycinIsoniazidPeptides, CyclicPharmaceutical PreparationsPore Forming Cytotoxic Proteinsantimicrobial peptidescoumarin derivativesdrug-resistant tuberculosisisoniazid derivatives

Identifiers

PMID33276545
PMCPMC7729780

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.