ArticleBrain sciences2020
Covert Cognition in Disorders of Consciousness: A Meta-Analysis.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Care pathways for individuals with post-anoxic disorder of consciousness (CaPIADoC): an inter-society Consensus Conference.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Meta-analysis of the diagnostic value of functional magnetic resonance imaging for distinguishing unresponsive wakefulness syndrome/vegetative state and minimally conscious state.Frontiers in neuroscience · 2024Pooled it
- What names for covert awareness? A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Common Consent Elements for Research Involving Persons with Disorders of Consciousness (CCE-DOC).Neurocritical care · 2026Article
- Disorders of Consciousness in Acute Care: Application of the CRS-R and Respiratory, Swallowing, and Discharge Outcomes at a Level 1 Trauma Hospital.Archives of rehabilitation research and clinical translation · 2026Article
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Assessing the Accuracy of ChatGPT in Answering Questions About Prolonged Disorders of Consciousness.Brain sciences · 2025Article
- Clinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation: Lessons Learned in an Acute Care Hospital.Neurology. Clinical practice · 2025Article
- Consensus on covert awareness: a Delphi study.Brain communications · 2025Article
- Disorders of Consciousness, Language and Communication Following Severe Brain Injury.Psychologica Belgica · 2025Review
- Cognitive Motor Dissociation in Disorders of Consciousness.The New England journal of medicine · 2024Article
- Family caregivers improve the diagnostic accuracy of disorders of consciousness: from remote to near-bed auditory stimulation.European journal of physical and rehabilitation medicine · 2024Article
- Cognitive Motor Dissociation: Gap Analysis and Future Directions.Neurocritical care · 2024Article
- Disorders of Consciousness: Classification and Taxonomy.Physical medicine and rehabilitation clinics of North America · 2024Review
- Peripheral blood BDNF and soluble CAM proteins as possible markers of prolonged disorders of consciousness: a pilot study.Scientific reports · 2024Article
- Covert consciousness.NeuroRehabilitation · 2024Article
- Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging.Neurocritical care · 2023Article
- Self-processing in coma, unresponsive wakefulness syndrome and minimally conscious state.Frontiers in human neuroscience · 2023Article
- Treatable brain network biomarkers in children in coma using task and resting-state functional MRI: a case series.Frontiers in neurology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Covert cognition in patients with disorders of consciousness represents a real diagnostic conundrum for clinicians. In this meta-analysis, our main objective was to identify clinical and demographic variables that are more likely to be associated with responding to an active paradigm. Among 2018 citations found on PubMed, 60 observational studies were found relevant. Based on the QUADAS-2, 49 studies were considered. Data from 25 publications were extracted and included in the meta-analysis. Most of these studies used electrophysiology as well as counting tasks or mental imagery. According to our statistical analysis, patients clinically diagnosed as being in a vegetative state and in a minimally conscious state minus (MCS-) show similar likelihood in responding to active paradigm and responders are most likely suffering from a traumatic brain injury. In the future, multi-centric studies should be performed in order to increase sample size, with similar methodologies and include structural and functional neuroimaging in order to identify cerebral markers related to such a challenging diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.