Evidence map›Paper›PMID 33276427›Full record

ReviewInternational journal of molecular sciences2020

IP3R Channels in Male Reproduction.

Xiaoning Zhang, Rongzu Huang, Yang Zhou, Wenwen Zhou, Xuhui Zeng

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaoning ZhangInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.ORCID 0000-0003-1227-866X
Rongzu HuangInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Yang ZhouInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Wenwen ZhouInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Xuhui ZengInstitute of Reproductive Medicine, Medical School, Nantong University, Nantong 226019, China.
Nantong University · CNNanchang University · CN

Funding

China Scholarship Council 201906825011National Key Research and Development Program of China 2018YFC1003500National Natural Science Foundation of China 81760283 and 31801238Natural Science Foundation of Jiangxi Province 20165BCB18001
6 · The paper itself

Abstract

As a second messenger in cellular signal transduction, calcium signaling extensively participates in various physiological activities, including spermatogenesis and the regulation of sperm function. Abnormal calcium signaling is highly correlated with male infertility. Calcium signaling is mainly regulated by both extracellular calcium influx and the release of calcium stores. Inositol 1,4,5-trisphosphate receptor (IP3R) is a widely expressed channel for calcium stores. After being activated by inositol 1,4,5-trisphosphate (IP3) and calcium signaling at a lower concentration, IP3R can regulate the release of Ca

Indexed as

AnimalsCalciumCalcium SignalingDisease SusceptibilityGene Expression RegulationHumansInfertility, MaleInositol 1,4,5-Trisphosphate ReceptorsMaleReproductionSex FactorsSignal TransductionSpermatogenesisSpermatozoaStructure-Activity RelationshipCalciumInositol 1,4,5-Trisphosphate Receptorscalcium signalinginfertilityIP3Rmale reproductionspermatogenesissperm function

Identifiers

PMID33276427
PMCPMC7730405
OpenAlexW3110080702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.