ArticleHuman molecular genetics2021
Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study.
Article in Human molecular genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity's influence on breast cancer risk.Science advances · 2026Pooled it
- Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Genome-wide mapping of common and rare variant effects on adiposity across childhood.Nature genetics · 2026Article
- Adolescent weight gain trajectories and their associations with biological aging: a genetically informed study.International journal of obesity (2005) · 2026Article
- Longitudinal prediction of BMI using explainable AI: integrating polygenic scores, maternal, early-life and familial factors.International journal of obesity (2005) · 2026Observational
- Disentangling the Effect of BMI on Hepatocellular Carcinoma From Cirrhosis With Multivariable Mendelian Randomization.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- A structural mean modeling Mendelian randomization approach to investigate the lifecourse effect of adiposity: applied and methodological considerations.American journal of epidemiology · 2026Article
- Child-To-Adult Body Size Change and Risk of Depression and Anxiety: A Large Prospective Cohort Study.Depression and anxiety · 2026Article
- Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention.Hormone research in paediatrics · 2026Review
- Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes.BMC medicine · 2025Article
- Associations of child-to-adult body size change with risk of hypertension and metabolic dysfunction-associated steatotic liver disease: a population-based cohort study of 226,420 individuals.BMC public health · 2025Article
- Mediterranean diet and obesity polygenic risk interaction on adiposity in European children: The IDEFICS/I.Family Study.Pediatric obesity · 2025Article
- Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study?International journal of obesity (2005) · 2025Article
- The role of body image dissatisfaction in the relationship between body size and disordered eating and self-harm: complimentary Mendelian randomization and mediation analyses.Molecular psychiatry · 2025Article
- Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study.Journal of obesity & metabolic syndrome · 2025Article
- Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study.BMC medicine · 2025Article
- Mammographic density mediates the protective effect of early-life body size on breast cancer risk.Nature communications · 2024Article
- Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease.Diabetologia · 2024Article
- Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization.Journal of the American Heart Association · 2024Article
- Separating the effects of life course adiposity on diabetic nephropathy: a comprehensive multivariable Mendelian randomization study.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
From a life-course perspective, genetic and environmental factors driving childhood obesity may have a lasting influence on health later in life. However, how obesity trajectories vary throughout the life-course remains unknown. Recently, Richardson et al. created powerful early life and adult gene scores for body mass index (BMI) in a comprehensive attempt to separate childhood and adult obesity. The childhood score was derived using questionnaire-based data administered to adults aged 40-69 regarding their relative body size at age 10, making it prone to recall and misclassification bias. We therefore attempted to validate the childhood and adult scores using measured BMI data in adolescence and adulthood among 66 963 individuals from the HUNT Study in Norway from 1963 to 2019. The predictive performance of the childhood score was better in adolescence and early adulthood, whereas the predictive performance of the adult score was better in adulthood. In the age group 12-15.9 years, the variance explained by the childhood polygenic risk score (PRS) was 6.7% versus 2.4% for the adult PRS. In the age group 24-29.9 years, the variance explained by the adult PRS was 3.9% versus 3.6% for the childhood PRS. Our findings support that genetic factors driving BMI differ at young age and in adulthood. Within the framework of multivariable Mendelian randomization, the validated childhood gene score can now be used to determine the consequence of childhood obesity on later disease.
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