Evidence map›Paper›PMID 33276263›Full record

ArticleHealth & place2021

Failure is not an option: Barriers to HIV treatment adherence in Kampala, Uganda.

Gabrielle Bruser, Ritah Katasi, Lily Ziyue Zhang, Miriam Namasinga, Eric Arts, Cissy Kityo, Isaac Luginaah

Open access · greenAbstract read
In one paragraph

Article in Health & place, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. "African geographical review · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gabrielle BruserDepartment of Geography, Western University, Social Science Centre, 1151 Richmond St, London, Ontario, N6A 5C2, Canada. Electronic address: gbruser@uwo.ca.
Ritah KatasiJoint Clinical Research Center, Lubowa Hill, Plot 101 Entebbe Road P. O. Box 10005, Wakiso District, Uganda. Electronic address: katasi12@gmail.com.
Lily Ziyue ZhangGlobal Health Systems, Western University, Schulich Medicine & Dentistry, 1151 Richmond St, London, Ontario, N6A 5C1, Canada. Electronic address: zzha72@uwo.ca.
Miriam NamasingaJoint Clinical Research Center, Lubowa Hill, Plot 101 Entebbe Road P. O. Box 10005, Wakiso District, Uganda. Electronic address: miriamnamasinga@gmail.com.
Eric ArtsDepartment of Microbiology & Immunology, Western University, Dental Science Building, 1151 Richmond St, London, Ontario, N6A 5C1, Canada. Electronic address: earts@uwo.ca.
Cissy KityoJoint Clinical Research Center, Lubowa Hill, Plot 101 Entebbe Road P. O. Box 10005, Wakiso District, Uganda. Electronic address: ckityo@jcrc.org.ug.
Isaac LuginaahDepartment of Geography, Western University, Social Science Centre, 1151 Richmond St, London, Ontario, N6A 5C2, Canada. Electronic address: iluginaa@uwo.ca.
Western University · CAJoint Clinical Research Centre · UG

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Alan David Levine · 1994 to 2026
$50.0M
Impact of HIV-1 Fitness on Disease ProgressionR01AI049170 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI ARTS, ERIC J · 2002 to 2024
$6.8M
HIV-1 Fitness and RecombinationR56AI049170 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ARTS, ERIC J · 2012 to 2012
$400k
Impact of HIV-1 Fitness on Disease ProgressionR21AI049170 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ARTS, ERIC J · 2001 to 2001
$265k
NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI049170NIAID NIH HHS R21 AI049170NIAID NIH HHS R56 AI049170
6 · The paper itself

Abstract

This study seeks to investigate challenges to combined antiretroviral therapy (cART) treatment adherence and treatment outcomes in Kampala, Uganda. Data was collected from a survey administered to two cohorts of patients with human immunodeficiency virus type 1 (HIV-1) receiving care and cART from the Joint Clinical Research Center (JCRC) in Kampala. Cohort I consisted of 93 individuals successfully treated on cART for a period of three years, while Cohort II consisted of 56 individuals who have experienced treatment failure with first-line cART within two years. We hypothesize that distance to the treatment facility would be a predictor of poor adherence and thus treatment failure. However, results suggested otherwise, whereby participants living more than 2 h away from their treatment facility were actually less likely to miss their daily dose of cART (OR = 0.33, p < .05), compared to those living in proximity to the treatment center. Further, high-income employment (OR = 3.82, p < .05) and partnered relationship status (OR = 4.28, p < .05) were predicted to increase the probability of missing doses. These findings may be explained by the deep-seated stigma which has remained pervasive in the lives of HIV-positive population in Kampala, even 30 years after the peak of the HIV/AIDS epidemic.

Indexed as

Acquired Immunodeficiency SyndromeHIV-1HIV InfectionsHumansTreatment Adherence and ComplianceUgandaAdherenceAntiretroviral therapyHIV/AIDSStigmaUganda

Identifiers

PMID33276263
PMCPMC10103613
OpenAlexW3107087396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.