ArticleMolecular cell2020
The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension.
Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Haloperidol drug repurposing unveils ferroptosis involvement in breast cancer cells.Scientific reports · 2025Article
- Construction of a ferroptosis-based prognostic model for breast cancer helps to discriminate high/low risk groups and treatment priority.Frontiers in immunology · 2023Article
- EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma.Cell death and differentiation · 2022Article
- Metabolic regulation of ferroptosis in the tumor microenvironment.The Journal of biological chemistry · 2022Review
- Insamgobonhwan Protects Neuronal Cells from Lipid ROS and Improves Deficient Cognitive Function.Antioxidants (Basel, Switzerland) · 2022Article
- CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR.Frontiers in oncology · 2022Article
- The three-dimension preclinical models for ferroptosis monitoring.Frontiers in bioengineering and biotechnology · 2022Review
- Identification of a ferroptosis-related gene signature predictive model in colon cancer.World journal of surgical oncology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Takahashi et al. (2020) conduct a focused CRISPR/Cas9 screen against NRF2 target and other redox regulatory genes in both 2D- and 3D-culture systems, uncovering a vulnerability of spheroid cancer cells deprived of extracellular matrix to undergo ferroptosis.
Indexed as
Identifiers
33275886What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.