Evidence map›Paper›PMID 33275634›Full record

Trial reportPloS one2020

Immunomodulatory drugs in multiple myeloma: Impact of the SCARMET (Self CARe and MEdication Toxicity) educational intervention on outpatients' knowledge to manage adverse effects.

Juliette Périchou, Florence Ranchon, Chloé Herledan, Laure Huot, Virginie Larbre, Isabelle Carpentier, Anne Lazareth, Lionel Karlin, Karen Beny, Nicolas Vantard and 8 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Impact of the ONCORAL multidisciplinary city-hospital follow-up on older patients with cancer treated with oral anticancer drugs.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  3. 15 years supporting adherence to oral anti-cancer treatment: use of the MASCC Oral Agent Teaching Tool (MOATT) worldwide, a review for the future.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Juliette PérichouUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Florence RanchonUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.ORCID 0000-0002-9181-4231
Chloé HerledanUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Laure HuotDépartement de la Recherche Clinique et de l'Innovation, Cellule Innovation, Hospices Civils de Lyon, Lyon, France.
Virginie LarbreUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Isabelle CarpentierPharmacie Centrale, Hospices Civils de Lyon, Pierre-Bénite, France.
Anne LazarethHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Lionel KarlinHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Karen BenyPharmacie Centrale, Hospices Civils de Lyon, Pierre-Bénite, France.
Nicolas VantardUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Vérane SchwiertzUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Anne Gaelle CaffinUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Amandine BaudouinUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Pierre SesquesHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Gabriel BrisouHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Hervé GhesquièresHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Gilles SallesHematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Catherine RioufolUnité de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Université Claude Bernard Lyon 1 · FRHospices Civils de Lyon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term multiple myeloma therapy by immunomodulatory drugs (IMiDs) raises the question of management of adverse effects. The aim of this study is to assess the impact of an educational session for patients on the acquisition of knowledge to manage hematologic and thromboembolic adverse effects of IMiDs. In this prospective single-center study, patients attended an educational session with a hospital clinical pharmacist and a nurse. The primary endpoint was the patient's level of knowledge for the management of IMiDs adverse effects, assess with a dedicated questionnaire administered before the session then 1 and 6 months after. Assessment of knowledge was combined with self-assessment of certainty. The secondary endpoints were adherence and IMiD treatment satisfaction. 50 patients were included. Patient knowledge increased at 1 month (p<0.001) despite a loss of knowledge at 6 months (p<0.05). Six months after the educational intervention, the number of patients with skills considered satisfactory by the pharmacist and nurse increased (p<0.01). Most patients showed satisfactory adherence, with medication possession ratio ≥ 80%. The Self CARe and MEdication Toxicity (SCARMET) study highlighted the impact of multidisciplinary follow-up in multiple myeloma patients to improve knowledge of toxicity self-management.

Indexed as

Patient Education as TopicSelf CareAgedAged, 80 and overFemaleFollow-Up StudiesHumansImmunologic FactorsMaleMiddle AgedMultiple MyelomaImmunologic Factors

Identifiers

PMID33275634
PMCPMC7717911
OpenAlexW3106834483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.