ArticlePloS one2020
Survival features, prognostic factors, and determinants of diagnosis and treatment among Iranian patients with pancreatic cancer, a prospective study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association between prediagnostic risk factors and survival after colorectal cancer diagnosis in Golesten cohort study.Scientific reports · 2025Article
- Delays in Presentation, Diagnosis, and Treatment Among Patients With GI Cancer in Southwest Nigeria.JCO global oncology · 2024Article
- Improvement of esophageal cancer survival in Northeast Iran: A two-decade journey in a high-risk, low- resource region.PloS one · 2024Article
- Incidence and risk factors of pancreatic cancer during 15 years follow-up in the Golestan Cohort Study in Iran.PloS one · 2024Article
- Aspirin Use and Risk of Pancreatic Ductal Adenocarcinoma: A Large Case-Control Study.Archives of Iranian medicine · 2023Article
- Pancreatic Cancer in Iran - Result of the Iranian National Cancer Registry Program.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Mortality Trends of Gastrointestinal, Liver, and Pancreaticobiliary Diseases: A Hospital-Based Prospective Study in the Southeast of Iran.Middle East journal of digestive diseases · 2022Article
- Association of social determinants of health with late diagnosis and survival of patients with pancreatic cancer.Journal of gastrointestinal oncology · 2022Article
- Gossypol Induces Apoptosis of Human Pancreatic Cancer Cells via CHOP/Endoplasmic Reticulum Stress Signaling Pathway.Journal of microbiology and biotechnology · 2022Article
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Authors and funding
12 authors.
Funding
Abstract
objectivesInvestigating the survival features, and determinants of treatment and stage at presentation in Iran.
methods461 patients with pancreatic ductal adenocarcinoma (PC) were prospectively enrolled from Shariati hospital, Tehran, Iran, between 2011-2018. All patients underwent endoscopic ultrasonography, computed tomography scanning, and physical examination. Validated questionnaire was completed for the participants and all were actively followed on monthly basis.
resultsMedian survival time was 6.5 months, and 1-, and 5-year survival rates were 26.2%, and 1.5%. Patients who were older (p<0.001), illiterate (p = 0.004), unmarried (p = 0.003), rural inhabitant (p = 0.013), opium user (p = 0.039), and had lower body mass index (BMI) (p = 0.002) had lower overall survival. Tumors located in the head of pancreas were more commonly diagnosed at lower stages (p<0.001). Only 10.4% of patients underwent surgery who were more commonly educated (p<0.001), married (p = 0.005), had a tumor located in the head of pancreas (p = 0.016), and were diagnosed at lower stages (p<0.001). After adjustment for potential confounders and risk factors, rural inhabitance (HR: 1.33 (95% CI: 1.01-1.74)), having more symptoms (HR for each increasing symptom: 1.06 (1.02-1.11)), using opium (HR: 1.51 (1.04-2.20)), having a tumor located in the body of pancreas (HR: 1.33 (1.02-1.75)), and having an advanced tumor stage (HR: 2.07 (1.34-3.19)) remained significantly associated with increased risk of mortality. After the adjusting for potential confounders, we did not find significant relationships between smoking, alcohol intake, and BMI with the risk of death among patients with pancreatic cancer.
conclusionsIranian patients with PC have very poor long-term survival. Besides tumor's stage and location, socioeconomic disparities could affect the probabilities of receiving treatment and/or survival in these patients. Opium use is an independent risk factor for mortality among PC patients in Iran.
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