Evidence map›Paper›PMID 33275522›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans.

Seth W Holwerda, Jason R Carter, Huan Yang, Jing Wang, Gary L Pierce, Paul J Fadel

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  5. Article
  6. Article
  7. Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  8. Resting beat-to-beat blood pressure variability is preserved in young adults with major depressive disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  9. Progressive baroreflex dysfunction and hypotension preceding VVS: a vicious cycle?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  10. The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  11. Article
  12. Article
  13. Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  14. Impact of maternal obesity on resting muscle sympathetic nerve activity during uncomplicated pregnancy: a longitudinal assessment.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  15. Article
  16. Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  17. Article
  18. Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  19. Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  20. Baroreflex responses to limb venous distension in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Seth W HolwerdaDepartment of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas.
Jason R CarterDepartment of Health and Human Development, Montana State University, Bozeman, Montana.
Huan YangDepartment of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts.
Jing WangCollege of Nursing, University of Texas at Arlington, Arlington, Texas.
Gary L PierceDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa.
Paul J FadelDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas.
The University of Texas at Arlington · USHarvard University · USMontana State University · USUniversity of Iowa · USUniversity of Kansas Medical Center · US

Funding

VASOPRESSIN IN CARDIOVASCULAR REGULATIONP01HL014388 · NHLBI · UNIVERSITY OF IOWA · PI ABBOUD, FRANCOIS M · 1985 to 2018
$40.3M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
INTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1M
Alcohol and Neurovascular Control in HumansR01AA024892 · NIAAA · MONTANA STATE UNIVERSITY - BOZEMAN · PI CARTER, JASON R · 2017 to 2021
$1.8M
Sympathetic Regulation of Large Artery Stiffness in Humans with Age-Related Isolated Systolic HypertensionR01AG063790 · NIA · UNIVERSITY OF IOWA · PI PIERCE, GARY L. · 2020 to 2024
$1.7M
Targeting Sympathetic Overactivity in CKD patients: Mechanisms & Novel TherapiesR01HL127071 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI FADEL, PAUL J · 2016 to 2019
$1.7M
NCATS NIH HHS UL1 TR002537NHLBI NIH HHS P01 HL014388NHLBI NIH HHS R01 HL127071NHLBI NIH HHS T32 HL007121NIAAA NIH HHS R01 AA024892NIA NIH HHS R01 AG063790
6 · The paper itself

Abstract

The use of spontaneous bursts of muscle sympathetic nerve activity (MSNA) to assess arterial baroreflex control of sympathetic nerve activity has seen increased utility in studies of both health and disease. However, methods used for analyzing spontaneous MSNA baroreflex sensitivity are highly variable across published studies. Therefore, we sought to comprehensively examine methods of producing linear regression slopes to quantify spontaneous MSNA baroreflex sensitivity in a large cohort of subjects (

Indexed as

BaroreflexAdolescentAdultAgedArterial PressureElectrodiagnosisFemaleHealthy VolunteersHeart RateHumansMaleMiddle AgedMuscle, SkeletalPredictive Value of TestsReproducibility of ResultsRetrospective Studiesblood pressuregainmodified OxfordMSNAreproducibility

Identifiers

PMID33275522
PMCPMC8082800
OpenAlexW3107238002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.