ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Endothelial cell disruption drives increased blood-brain barrier permeability and cerebral edema in the Dahl SS/jr rat model of superimposed preeclampsia.
Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- LncRNA UNC5C-AS1 inhibits angiogenesis and induces endothelial apoptosis via the miR-148a-3p/EMP1 axis in preeclampsia.Cell adhesion & migration · 2026Article
- Exploring the Mechanism of Postpartum Cognitive Dysfunction in a Preeclampsia Rat Model via Multimodal Imaging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- History of hypertensive disorders of pregnancy and risk of Alzheimer's disease and vascular dementia.Frontiers in neuroendocrinology · 2025Review
- Inhibitory effect of exercise on elevated blood pressure and fetal growth restriction during pregnancy in Dahl salt-sensitive rats.Physiological reports · 2025Article
- Structure and function of neurovascular unit in arterial hypertension.Frontiers in molecular neuroscience · 2025Review
- Mucormycosis during COVID-19 era: A retrospective assessment.Infectious medicine · 2024Review
- Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH-UP Criteria.Journal of the American Heart Association · 2024Article
- Blood-Brain Barrier Dysfunction in Hypertensive Disorders of Pregnancy.Current hypertension reports · 2023Review
- Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia.Pregnancy hypertension · 2023Article
- Preeclampsia history and postpartum risk of cerebrovascular disease and cognitive impairment: Potential mechanisms.Frontiers in physiology · 2023Review
- AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum.International journal of cerebrovascular disease and stroke · 2023Article
- Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History.International journal of molecular sciences · 2022Article
- Pathogenic mechanisms of preeclampsia with severe features implied by the plasma exosomal mirna profile.Bioengineered · 2021Article
- Neurology of Preeclampsia and Related Disorders: an Update in Neuro-obstetrics.Current pain and headache reports · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Preeclampsia is characterized by increases in blood pressure and proteinuria in late pregnancy, and neurological symptoms can appear in the form of headaches, blurred vision, cerebral edema, and, in the most severe cases, seizures (eclampsia). The causes for these cerebral manifestations remain unknown, so the use of animal models that mimic preeclampsia is essential to understanding its pathogenesis. The Dahl salt-sensitive (Dahl SS/jr) rat model develops spontaneous preeclampsia superimposed on chronic hypertension; therefore, we hypothesized that the Dahl SS/jr rat would display cerebrovascular features similar to those seen in human preeclampsia. Furthermore, we predicted that this model would allow for the identification of mechanisms underlying these changes. The pregnant Dahl SS/jr rat displayed increased cerebral edema and blood-brain barrier disruption despite tighter control of cerebral blood flow autoregulation and vascular smooth muscle myogenic tone. Analysis of cerebral endothelial cell morphology revealed increased opening of tight junctions, basement membrane dissolution, and vesicle formation. RNAseq analysis identified that genes related to endothelial cell tight junctions and blood-brain barrier integrity were differentially expressed in cerebral vessels from pregnant Dahl SS/jr compared with healthy pregnant Sprague Dawley rats. Overall, our data reveal new insights into mechanisms involved in the cerebrovascular dysfunction of preeclampsia.
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