ArticleEnvironmental health perspectives2020
Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Comparing effects of gaseous vs. particulate components of traffic-related air pollution on Alzheimer's disease biomarkers in a genetically susceptible rat model.Neurotoxicology · 2026Article
- Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Dantrolene normalizes heightened CaCell calcium · 2025Article
- Neighborhood environmental burden and the elderly's complete edentulism prevalence in the US.BMC public health · 2025Article
- Ambient Particulate Matter Exposure Impairs Gut Barrier Integrity and Disrupts Goblet Cell Function.Biomedicines · 2025Article
- The efficiency of EURO 6d car particulate filters is compromised by atmospheric aging: In vitro toxicity of gasoline car exhaust.Science advances · 2025Article
- Defining VOC signatures of airway epithelial cells with PM2.5 exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Proteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone.Cardiovascular toxicology · 2024Article
- Particulate air pollution exaggerates diet-induced insulin resistance through NLRP3 inflammasome in mice.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Probing changes in brain esterified oxylipin concentrations during the early stages of pathogenesis in Alzheimer's Disease transgenic rats.Neuroscience letters · 2022Article
- Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats.Environmental toxicology and pharmacology · 2022Article
- Emulating Near-Roadway Exposure to Traffic-Related Air Pollution via Real-Time Emissions from a Major Freeway Tunnel System.Environmental science & technology · 2022Article
- Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner.Frontiers in cellular neuroscience · 2022Article
- Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer's disease.Toxicology reports · 2022Article
- The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats.Environmental health perspectives · 2021Article
- Potential Mechanisms behind Air Pollution Toxicity: Findings from Real-World Chronic Exposures.Environmental health perspectives · 2021Article
- Aryl Hydrocarbon Receptor Signaling Synergizes with TLR/NF-κB-Signaling for Induction of IL-22 Through Canonical and Non-Canonical AhR Pathways.Frontiers in toxicology · 2021Article
- Air Pollution and Cardiac Diseases: A Review of Experimental Studies.Dose-response : a publication of International Hormesis SocietyReview
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10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundTraffic-related air pollution (TRAP) is made up of complex mixtures of particulate matter, gases and volatile compounds. However, the effects of TRAP on the cardiopulmonary system in most animal studies have been tested using acute exposure to singular pollutants. The cardiopulmonary effects and molecular mechanisms in animals that are chronically exposed to unmodified air pollution as a whole have yet to be studied. Additionally, sex-dependent toxicity of TRAP exposure has rarely been evaluated.
objectivesThis study sought to assess the cardiopulmonary effect of chronic exposure to unmodified, real-world TRAP in both female and male rats.
methodsFour-week-old male and female rats were exposed to TRAP or filtered air for 14 months in a novel facility drawing air from a major freeway tunnel system in Northern California. Inflammation and oxidative stress markers were examined in the lung, heart, spleen, and plasma, and TRAP deposits were quantified in the lungs of both male and female rats.
resultsElemental analysis showed higher levels of eight elements in the female lungs and one element in the male lungs. Expression of genes related to fibrosis, aging, oxidative stress, and inflammation were higher in the rat hearts exposed to TRAP, with female rats being more susceptible than males. Enhanced collagen accumulation was found only in the TRAP-exposed female hearts. Plasma cytokine secretion was higher in both female and male rats, but inflammatory macrophages were higher only in TRAP-exposed male spleens. DISCUSSION: Our results in rats suggest pathological consequences from chronic TRAP exposure, including sex differences indicating females may be more susceptible to TRAP-induced cardiac fibrosis. https://doi.org/10.1289/EHP7045.
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