Evidence map›Paper›PMID 33275179›Full record

ArticleEJNMMI radiopharmacy and chemistry2020

A simple and efficient automated microvolume radiosynthesis of [

Ksenia Lisova, Jia Wang, Philip H Chao, R Michael van Dam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ksenia LisovaPhysics & Biology in Medicine Interdepartmental Graduate Program, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3763-3173
Jia WangCrump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA.
Philip H ChaoCrump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA.
R Michael van DamPhysics & Biology in Medicine Interdepartmental Graduate Program, University of California Los Angeles, Los Angeles, CA, USA. mvandam@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Research Training in Biomedical PhysicsT32EB002101 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael F McNitt-Gray · 2003 to 2026
$5.3M
Commercialization of a Benchtop Radiosynthesizer for the Production of PET ProbesR44MH097271 · NIMH · SOFIE BIOSCIENCES, INC. · PI MOORE, MELISSA · 2013 to 2018
$3.8M
Optimization and validation of integrated microscale technologies for low-cost, automated production of PET molecular imaging tracers for cancer researchR33CA240201 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2019 to 2021
$1.1M
Automated microfluidic production of high specific activity PET tracers to enable routine CNS imagingR21AG049918 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2015 to 2017
$693k
High-throughput radiochemistry platform for accelerated discovery and development of novel PET imaging agents for cancerR21CA212718 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2017 to 2018
$616k
NCI NIH HHS R21 CA212718NCI NIH HHS R33 CA240201NIA NIH HHS R21 AG049918NIBIB NIH HHS T32 EB002101NIBIB NIH HHS T32 EB002101NIMH NIH HHS R44 MH 097271NIMH NIH HHS R44 MH097271
6 · The paper itself

Abstract

backgroundCurrent automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot be economically produced on a conventional synthesizer. Alternative approaches are desired to produce small to moderate batches to reduce cost and the amount of reagents and radioisotope needed to produce PET tracers with high molar activity. In this work we describe the first reported microvolume method for production of [ PROCEDURES: The microscale synthesis of [

resultsStarting with 270 ± 100 MBq (n = 3) of [

conclusionsThis work describes an efficient and reliable procedure to produce [

Indexed as

AutomationBeta-amyloid imagingDroplet synthesisFlorbetabenMicrofluidicsMolar activityRadiochemistryRadiolysis

Identifiers

PMID33275179
PMCPMC7718361
OpenAlexW3107919584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.