ReviewAdvanced healthcare materials2021
Multiple Pathways for Pathological Calcification in the Human Body.
Review in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 98 citations in OpenAlex.
- Structural and chemical heterogeneity of pulp stones in young untreated bovine incisors: frequent dentin-like mineralizations.Journal of structural biology: X · 2026Article
- A vascular calcification model enabled by aniScience · 2026Article
- Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Osteomimetic microcalcification shapes the breast tumor microenvironment and metastatic potential.Cancer metastasis reviews · 2026Review
- Cementum Attachment Protein-Derived Peptides Modulate Brushite and Calcium Oxalate Crystallization In Vitro.Journal of peptide science : an official publication of the European Peptide Society · 2026Article
- Heavily ossified renal mass as the initial presentation of primary renal osteosarcoma: a case report.CEN case reports · 2026Article
- From diagnostic marker-to-therapeutic modality: emerging paradigms in tumor biomineralization.Cancer biology & medicine · 2026Review
- Selection for Function in Early Life: Implications for Early-Onset Pathologies.Evolutionary applications · 2026Article
- Revealing Prostate Calcification Heterogeneity through Their Elemental Distribution.Chemical & biomedical imaging · 2025Article
- Biological and Biologically Inspired Functional Nanostructures: Insights into Structural, Optical, Thermal, and Sensing Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Comprehensive Review of Mechanisms and Translational Perspectives on Programmed Cell Death in Vascular Calcification.Biomolecules · 2025Review
- Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells.Structure (London, England : 1993) · 2025Article
- Amyloid-induced mineralization: From biological systems to biomimetic materials.Bioactive materials · 2025Review
- Mammographic Calcifications Add Uncertainty in Predicting Response to Neoadjuvant Chemotherapy.Radiology · 2025Article
- Examination of the Frequency of Soft Tissue Ossification and Calcifications in Panoramic Radiographs: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- Mechanisms of osteopontin-stabilized amorphous calcium phosphate calcification in benign and pre-malignant breast disease.Scientific reports · 2025Article
- Cartilage-SpecificBiomedicines · 2025Article
- Pyrophosphate-Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality.Advanced healthcare materials · 2025Article
- Tumor Hypoxia: How Conventional Histology Is Reshaped in Breast Carcinoma.International journal of molecular sciences · 2025Review
- Ductal Carcinoma In Situ: Non-Mass Enhancement on MRI 10 Years Before Mammographic Microcalcifications.Journal of the advanced practitioner in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Biomineralization of skeletal components (e.g., bone and teeth) is generally accepted to occur under strict cellular regulation, leading to mineral-organic composites with hierarchical structures and properties optimized for their designated function. Such cellular regulation includes promoting mineralization at desired sites as well as inhibiting mineralization in soft tissues and other undesirable locations. In contrast, pathological mineralization, with potentially harmful health effects, can occur as a result of tissue or metabolic abnormalities, disease, or implantation of certain biomaterials. This progress report defines mineralization pathway components and identifies the commonalities (and differences) between physiological (e.g., bone remodeling) and pathological calcification formation pathways, based, in part, upon the extent of cellular control within the system. These concepts are discussed in representative examples of calcium phosphate-based pathological mineralization in cancer (breast, thyroid, ovarian, and meningioma) and in cardiovascular disease. In-depth mechanistic understanding of pathological mineralization requires utilizing state-of-the-art materials science imaging and characterization techniques, focusing not only on the final deposits, but also on the earlier stages of crystal nucleation, growth, and aggregation. Such mechanistic understanding will further enable the use of pathological calcifications in diagnosis and prognosis, as well as possibly provide insights into preventative treatments for detrimental mineralization in disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.