ArticlePreventing chronic disease2020
Cost-Related Nonadherence and Mortality in Patients With Chronic Disease: A Multiyear Investigation, National Health Interview Survey, 2000-2014.
Article in Preventing chronic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Conduction System Pacing vs Biventricular Pacing in Chronic Heart Failure: Protocol for the Economic Analysis of the PhysioSync-HF Trial.Arquivos brasileiros de cardiologia · 2025Trial
- Association of Medication Adherence With Health Outcomes in the ISCHEMIA Trial.Journal of the American College of Cardiology · 2022Trial
- Trends in annual medication possession in older adults with type 2 diabetes.Journal of managed care & specialty pharmacy · 2026Article
- The Promises and Pitfalls of Real-time Benefit Tools: A Qualitative Study of Primary Care Providers.Journal of general internal medicine · 2026Article
- Interdisciplinary Perspectives on Patient Adherence to Therapy: Findings from a Qualitative Study.Healthcare (Basel, Switzerland) · 2026Article
- Patient out-of-pocket costs for antihypertensive single pill combination products with cost caps.Journal of human hypertension · 2026Article
- Inequities in the Hypertension and Diabetes Care Cascade: A Comparison of SES and Insurance in China, the US, and the UK.Healthcare (Basel, Switzerland) · 2026Article
- Duration of health insurance coverage gaps and subsequent cost-related barriers to care among adults aged 18-64 years with multimorbidity.Frontiers in public health · 2026Article
- Risk stratification and multidisciplinary management strategies for pregnancy complicated by pulmonary arterial hypertension: a narrative review.Frontiers in endocrinology · 2026Review
- Financial Hardship After Surgical Procedures.JAMA surgery · 2026Article
- Understanding Treatment Adherence in Chronic Diseases: Challenges, Consequences, and Strategies for Improvement.Journal of clinical medicine · 2025Review
- The Ongoing Need to Address Cost-Related Nonadherence to Diabetes Medications.Diabetes care · 2025Article
- Changes in cost-related nonadherence among US adults with multiple chronic conditions from 2019 to 2023.Journal of managed care & specialty pharmacy · 2025Article
- Association between Difficulty Affording Medications and Outcomes in Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2025Article
- Medications Redistributed and Their Estimated Value from One Drug Repository Program.Journal of general internal medicine · 2025Article
- The administrative burden of medication affordability resources: an environmental scan with implications for health informatics to advance health equity.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Adherence Labeling: Understanding the Origins, Limitations, and Ethical Challenges of "Diagnosing" Nonadherence.Annals of family medicine · 2025Article
- Cost-Related Medication Behaviors for Patients With and Without Systemic Autoimmune Rheumatic Diseases.Arthritis care & research · 2025Article
- Policy options for the drug pricing conundrum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- New integrations in patient care: the role of the pharmacist between couselling and medication adherence.Journal of preventive medicine and hygiene · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrescription costs are rising, and many patients with chronic illnesses have difficulty paying for prescriptions. Missing or delaying medication because of financial concerns is common; however, the effects of cost-related nonadherence (CRN) on patient outcomes have not been described. Our objective was to determine if CRN is associated with higher all-cause and disease-specific mortality among patients living with diabetes and cardiovascular disease in a representative sample of US adults.
methodsWe ascertained CRN, vital status, and cause of death for 39,571 patients with diabetes, 61,968 patients with cardiovascular disease, and 124,899 patients with hypertension in the 2000 through 2014 releases of the National Health Interview Survey. We used adjusted Cox proportional hazards models to estimate associations between CRN and all-cause mortality and CRN and disease-specific mortality.
resultsOn average, 15% of the sample reported CRN in the year before interview. After adjusting for confounders, CRN was associated with 15% to 22% higher all-cause mortality rates for all conditions (diabetes hazard ratio [HR] = 1.18; 95% CI, 1.1-1.3; cardiovascular disease [CVD] HR = 1.15; 95% CI, 1.1-1.2; hypertension HR = 1.22; 95% CI, 1.2-1.3). Relative to no CRN, CRN was associated with 8% to 18% higher disease-specific mortality rates (diabetes HR = 1.18; 95% CI, 1.0-1.4; CVD HR = 1.09; 95% CI, 1.0-1.2; hypertension HR = 1.08; 95% CI, 0.9-1.3).
conclusionRelative to full adherence, CRN is associated with higher mortality rates for patients with diabetes, cardiovascular disease, and hypertension, although associations may have weakened since 2011. Policies that increase prescription affordability may decrease mortality for patients experiencing CRN.
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