Observational studyOrthopaedic surgery2021
Bone Cement Implantation Syndrome in Bone Tumor Surgeries: Incidence, Risk Factors, and Clinical Experience.
Observational study in Orthopaedic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Bone cement implantation syndrome: a scoping review.British journal of anaesthesia · 2025Article
- Enhanced clinical outcomes of uncemented prostheses in revision surgery of distal femoral tumor prostheses: a retrospective study.European journal of medical research · 2025Article
- Bone cement implantation syndrome in patients with cemented endoprostheses for metastatic bone disease in the femur.Journal of bone oncology · 2025Article
- [Research progress in etiology and prevention of bone cement implantation syndrome].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Evaluating the risk factors for bone cement implantation syndrome in hip surgeries - A cross sectional observational study.Bioinformation · 2025Article
- A Novel Implant Design for Cemented Endoprosthesis Stems to Reduce the Risk of Bone Cement Implantation Syndrome.Cureus · 2025Article
- Perioperative Blood Pressure Optimization to Improve Outcomes in Orthopedic Patients: A Clinical Review.Therapeutics and clinical risk management · 2025Review
- Cemented vs uncemented megaprostheses in proximal femur metastases: a multicentric comparative study.BMC musculoskeletal disorders · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the incidence and risk factors of bone cement implantation syndrome (BCIS) in bone tumor surgeries.
methodsThis was a retrospective observational study. We investigated patients who underwent bone tumor surgeries requiring cementation as part of the surgery between March 2016 and January 2018. We reviewed medical records, including formal anesthesia records and operation notes. Patients with complete data files were included. To investigate the general incidence of BCIS in tumor surgeries, patients of all ages, genders and tumor types were included. Vital signs, including oxygen saturation, blood pressure, heart rate, and respiratory rate, were checked and recorded once every 1-2 min after cementation. Accurate time points of cementation were recorded on formal anesthesia record sheets by the anesthesiologists. The definition and severity of BCIS were based on the classification system proposed in previous studies: grade I, moderate hypoxia (SpO
resultsA total of 88 patients were included. BCIS occurred in 23 patients, with an incidence of 26.1%. Among them, 19 had grade I and 4 had grade II BCIS. There was no patients with grade III BCIS. The lowest blood pressure occurred within 10 min in 21 (87.5%) patients and within 20 min for all patients. A total of 9 grade I BCIS were self-limiting. The other 10 grade I hypotension cases and all grade II hypotension cases recovered after administration of a vasoconstrictor medication. Preexisting lung cancer or lung metastasis was the risk factor for BCIS; 40.0% of patients (16 in 40 patients) with preexisting lung cancer or metastasis had BCIS, whereas only 14.6% of patients (7 in 48 patients) without lung lesions had BCIS. There was no risk difference in terms of arthroplasty, old age, and increased blood loss. Apart from grades I and II bone cement implantation syndrome, there were no other major complications, including death, cardiovascular events, or cerebrovascular events.
conclusionBone cement implantation syndrome is not unusual in bone tumor surgeries, and preexisting lung cancer or lung metastasis is a risk factor.
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