ArticleSleep2021
Residual, differential neurobehavioral deficits linger after multiple recovery nights following chronic sleep restriction or acute total sleep deprivation.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Short sleep recovery partially restores decision-making alterations induced by total sleep deprivation.Sleep advances : a journal of the Sleep Research Society · 2026Article
- The night shift brain: functional network reorganization in sleep-deprived medical staff.Frontiers in human neuroscience · 2026Article
- The Sleep Opportunity, Need and Ability (SONA) Theory.Journal of sleep research · 2025Review
- Bidirectional Predictors Between Neurobehavioural Measures During Total Sleep Deprivation and Baseline and Recovery Sleep Measures.Journal of sleep research · 2025Article
- Bidirectional predictors between baseline and recovery sleep measures and cardiovascular measures during sleep deprivation and psychological stress.Physiological reports · 2025Article
- Changes in sleep architecture during recurrent cycles of sleep restriction: a comparison between stable and variable short sleep schedules.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Correlation Between Monocyte Count, Monocyte-Lymphocyte Ratio, and Other Inflammatory Cells With Sleep and Psychiatric Symptoms in First-Episode Schizophrenia Patients.Neuropsychiatric disease and treatment · 2025Article
- Targeted memory reactivation with sleep disruption does not weaken week-old memories.NPJ science of learning · 2024Article
- Short-term and long-term phenotypic stability of actigraphic sleep metrics involving repeated sleep loss and recovery.Journal of sleep research · 2024Article
- Effects of non-rapid eye movement sleep on the cortical synaptic expression of GluA1-containing AMPA receptors.The European journal of neuroscience · 2024Article
- Bright Light Therapy for Major Depressive Disorder in Adolescent Outpatients: A Preliminary Study.Clocks & sleep · 2024Article
- Total sleep deprivation alters spontaneous brain activity in medical staff during routine clinical work: a resting-state functional MR imaging study.Frontiers in neuroscience · 2024Article
- A narrative review of the pathophysiology and impacts of insufficient and disrupted sleep.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Review
- Total sleep deprivation impairs visual selective attention and triggers a compensatory effect: evidence from event-related potentials.Cognitive neurodynamics · 2023Article
- One night of 10-h sleep restores vigilance after total sleep deprivation: the role of delta and theta power during recovery sleep.Sleep and biological rhythms · 2023Article
- Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recent Progress in Long-Term Sleep Monitoring Technology.Biosensors · 2023Review
- Article
- Fatigue and Its Contributing Factors in Chinese Patients with Primary Pituitary Adenomas.Journal of oncology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesThe amount of recovery sleep needed to fully restore well-established neurobehavioral deficits from sleep loss remains unknown, as does whether the recovery pattern differs across measures after total sleep deprivation (TSD) and chronic sleep restriction (SR).
methodsIn total, 83 adults received two baseline nights (10-12-hour time in bed [TIB]) followed by five 4-hour TIB SR nights or 36-hour TSD and four recovery nights (R1-R4; 12-hour TIB). Neurobehavioral tests were completed every 2 hours during wakefulness and a Maintenance of Wakefulness Test measured physiological sleepiness. Polysomnography was collected on B2, R1, and R4 nights.
resultsTSD and SR produced significant deficits in cognitive performance, increases in self-reported sleepiness and fatigue, decreases in vigor, and increases in physiological sleepiness. Neurobehavioral recovery from SR occurred after R1 and was maintained for all measures except Psychomotor Vigilance Test (PVT) lapses and response speed, which failed to completely recover. Neurobehavioral recovery from TSD occurred after R1 and was maintained for all cognitive and self-reported measures, except for vigor. After TSD and SR, R1 recovery sleep was longer and of higher efficiency and better quality than R4 recovery sleep.
conclusionsPVT impairments from SR failed to reverse completely; by contrast, vigor did not recover after TSD; all other deficits were reversed after sleep loss. These results suggest that TSD and SR induce sustained, differential biological, physiological, and/or neural changes, which remarkably are not reversed with chronic, long-duration recovery sleep. Our findings have critical implications for the population at large and for military and health professionals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.