Evidence map›Paper›PMID 33274280›Full record

ArticleACS central science2020

Precisely Structured Nitric-Oxide-Releasing Copolymer Brush Defeats Broad-Spectrum Catheter-Associated Biofilm Infections

Zheng Hou, Yang Wu, Chen Xu, Sheethal Reghu, Zifang Shang, Jingjie Chen, Dicky Pranantyo, Kalisvar Marimuth, Partha Pratim De, Oon Tek Ng and 4 more

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Antifouling Zwitterionic Polymer Coatings for Blood-Bearing Medical Devices.Langmuir : the ACS journal of surfaces and colloids · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Potent, Broad-Spectrum Antimicrobial Effects ofACS applied bio materials · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Zheng HouSchool of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459.
Yang WuSchool of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459.
Chen XuSchool of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459.
Sheethal ReghuSchool of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459.
Zifang ShangFrontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 1 Dongxiang Road Changan District, Xi'an 710072, China.
Jingjie ChenFrontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 1 Dongxiang Road Changan District, Xi'an 710072, China.
Dicky PranantyoDepartment of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Kent Ridge, Singapore 117585.
Kalisvar MarimuthTan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
Partha Pratim DeTan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
Oon Tek NgLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.
Kevin PetheLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.
En-Tang KangDepartment of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Kent Ridge, Singapore 117585.
Peng LiFrontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 1 Dongxiang Road Changan District, Xi'an 710072, China.
Mary B Chan-ParkSchool of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459.
Nanyang Technological University · SGNational University of Singapore · SGNorthwestern Polytechnical University · CNTan Tock Seng Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacteria cannot be easily eradicated by antibiotics and are a major source of recalcitrant infections of indwelling medical devices. Among various device-associated infections, intravascular catheter infection is a leading cause of mortality. Prior approaches to surface modification, such as antibiotics impregnation, hydrophilization, unstructured NO-releasing, etc., have failed to achieve adequate infection-resistant coatings. We report a precision-structured diblock copolymer brush (H(N)-

Identifiers

PMID33274280
PMCPMC7706084
OpenAlexW3095468424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.