Evidence map›Paper›PMID 33274275›Full record

ArticleACS central science2020

Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s.

Dedai Lu, Jiachen Wang, Yunfei Li, Yongyong Zhang, Lili Yu, Tingting Xu, Hongyun Guo, Yongdong Zhang, Xingdong Wang, Xiaoqi Wang and 2 more

Abstract read
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In one paragraph

Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dedai LuKey Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Jiachen WangKey Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Yunfei LiKey Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Yongyong ZhangKey Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Lili YuKey Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Tingting XuJiangsu Key Laboratory of Molecular Imaging and Function Imaging, Department of Radiology, Zhongda Hospital Southeast University, School of Medicine, Southeast University, Nanjing 210009, China.
Hongyun GuoInstitute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China.
Yongdong ZhangInstitute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China.
Xingdong WangInstitute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China.
Xiaoqi WangInstitute of Gansu Medical Science Research, Gansu Provincial Cancer Hospital, Lanzhou 730050, China.
Gaojun TengJiangsu Key Laboratory of Molecular Imaging and Function Imaging, Department of Radiology, Zhongda Hospital Southeast University, School of Medicine, Southeast University, Nanjing 210009, China.
Ziqiang LeiKey Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter arterial embolization (TAE) has been widely applied in treatments of unresectable or hypervascular tumors, but the procedure of TAE is complicated possibly brings inherent risks. Here, inspired by pH-responsive drug delivery systems, a new method of noninvasive and target embolization therapy by intravenous injection was developed. This method is based on a type of acidic microenvironment-responsive hyperbranched poly(amino acid) (HPTTG) to avoid using catheterization and real-time image guidance angiography, simplifying the procedure, elevating compliance and general applicability of embolization therapy. The pH value of the sol-to-gel phase transition with decreasing pH of HPTTG was controlled by adjusting the ratio of acidic amino acids in copolymers. The results of the tumor-bearing animal experiment indicate that the HPTTG have an excellent target and embolic ability; they accumulate the most at the tumor site in 8 h postinjection. Blood vessels of the tumors were occluded, and the tumors were inhibited and necrotized in about 20 days. Therefore, it is expected that HPTTG not only can be used as novel embolic materials for efficient noninvasive embolization therapy of many solid tumors but also can be used as a multifunctional platform for combined theranostics, for example, combination with controlled release, thermal ablation, multimodal imaging, synergistic therapy, etc.

Identifiers

PMID33274275
PMCPMC7706070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.