Evidence map›Paper›PMID 33274237›Full record

ReviewJournal of diabetes research2020

Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment.

Rajya L Gurung, Liesel M FitzGerald, Bennet J McComish, Nitin Verma, Kathryn P Burdon

Open access · goldAbstract readReview
In one paragraph

Review in Journal of diabetes research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rajya L GurungMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.ORCID https://orcid.org/0000-0003-0816-9823
Liesel M FitzGeraldMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.ORCID https://orcid.org/0000-0002-6882-2698
Bennet J McComishMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.ORCID https://orcid.org/0000-0003-1940-0007
Nitin VermaSchool of Medicine, University of Tasmania, Hobart, TAS, Australia.ORCID https://orcid.org/0000-0002-4753-9172
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.ORCID https://orcid.org/0000-0001-8217-1249
University of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM). DR is complex and the term encompasses several clinical subtypes of diabetic eye disease, including diabetic macular edema (DME), the most frequent cause of central vision loss in DR patients. Both genetic and environmental factors contribute to the pathophysiology of DR and its subtypes. While numerous studies have identified several susceptibility genes for DR, few have investigated the impact of genetics on DME susceptibility. This review will focus on the current literature surrounding genetic risk factors associated with DME. We will also highlight the small number of studies investigating the genetics of response to antivascular endothelial growth factor (anti-VEGF) injection, which is used to treat DME.

Indexed as

Aldehyde ReductaseAngiogenesis InhibitorsApolipoproteins EBevacizumabDiabetic RetinopathyErythropoietinEye ProteinsGenetic Predisposition to DiseaseHumansMacular EdemaMicroRNAsNerve Growth FactorsNitric Oxide SynthasePigment Epithelium-Derived FactorRanibizumabReceptors, Vascular Endothelial Growth FactorafliberceptAKR1B1 protein, humanAldehyde ReductaseAngiogenesis InhibitorsApolipoproteins EBevacizumabEPO protein, humanErythropoietinEye ProteinsMicroRNAsNerve Growth FactorsNitric Oxide SynthasePigment Epithelium-Derived FactorRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsSerpinsSuperoxide DismutaseSuperoxide Dismutase 2Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVEGFA protein, humanVEGFC protein, human

Identifiers

PMID33274237
PMCPMC7683113
OpenAlexW3102847973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.