Evidence map›Paper›PMID 33274195›Full record

ArticleBioMed research international2020

Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis.

Jayasinghe Arachchige Nirosha Sandamali, Ruwani Punyakanthi Hewawasam, Madappuli Arachchige Chaminda Sri Sampath Fernando, Kamani Ayoma Perera Wijewardana Jayatilaka, Ranji Duleep Madurawe, Periyasamy Pillai Sathananthan, Upul Ekanayake, Jayamini Horadugoda

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Doxorubicin-induced cardiotoxicity and risk factors.International journal of cardiology. Heart & vasculature · 2024
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jayasinghe Arachchige Nirosha SandamaliDepartment of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Ruhuna, Galle, Sri Lanka.ORCID https://orcid.org/0000-0002-3491-9600
Ruwani Punyakanthi HewawasamDepartment of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.ORCID https://orcid.org/0000-0001-6349-4755
Madappuli Arachchige Chaminda Sri Sampath FernandoDepartment of Economics & Statistics, Faculty of Social Sciences & Languages, Sabaragamuwa University of Sri Lanka, Belihuloya, Sri Lanka.
Kamani Ayoma Perera Wijewardana JayatilakaDepartment of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.ORCID https://orcid.org/0000-0002-6714-0273
Ranji Duleep MaduraweTeaching Hospital, Karapitiya, Sri Lanka.
Periyasamy Pillai SathananthanTeaching Hospital, Karapitiya, Sri Lanka.
Upul EkanayakeTeaching Hospital, Karapitiya, Sri Lanka.
Jayamini HoradugodaTeaching Hospital, Karapitiya, Sri Lanka.
Teaching Hospital Kandy · LKUniversity of Ruhuna · LKSabaragamuwa University of Sri Lanka · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthracycline-induced cardiotoxicity has never been investigated in Sri Lanka. Therefore, this study was conducted to determine the prevalence of anthracycline-induced cardiotoxicity in breast cancer patients using echocardiographic findings. A prospective cohort study was performed. All newly diagnosed breast cancer patients who were administered with anthracycline and cyclophosphamide (AC schedule) for the first time were enrolled in the study. In the hospital setting, anthracycline is administered only as a combination therapy, and only this combination was selected to limit the effect of other cardiotoxic chemotherapy agents. Records of echocardiography were obtained: one day before anthracycline chemotherapy (baseline), one day after the first chemotherapy dose, one day after the last chemotherapy dose, and six months after the completion of anthracycline chemotherapy. Following parameters were recorded from the echocardiography results: ejection fraction (EF, %), fractioning shortening (FS, %), posterior wall thickness, left ventricle (PWT, mm), the thickness of interventricular septum (IVS, mm), left ventricular end-diastolic diameter (LVEDD, mm), and left ventricular end-systolic diameter (LVESD, mm). Statistical analysis of the echocardiography results was performed using ANOVA at four stages. A

Indexed as

EchocardiographyAgedAnthracyclinesBreast NeoplasmsCardiotoxicityFemaleHumansLinear ModelsMiddle AgedRisk FactorsSri LankaStroke VolumeAnthracyclines

Identifiers

PMID33274195
PMCPMC7683106
OpenAlexW3100263402

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.