Culturing Articular Cartilage Explants in the Presence of Autologous Adipose Tissue Modifies Their Inflammatory Response to Lipopolysaccharide.

Wendy Pearson, Anna E N Garland, Ashley Nixon, John P Cant, Mark B Hurtig

Open access · goldAbstract read

In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Gastrin and Nitric Oxide Production in Cultured Gastric Antral Mucosa Are Altered in Response to a Gastric Digest of a Dietary Supplement.Frontiers in veterinary science · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wendy PearsonDepartment of Animal Biosciences, University of Guelph, Guelph, ON, Canada N1G 2W1.ORCID https://orcid.org/0000-0002-3635-4594

Anna E N GarlandDepartment of Animal Biosciences, University of Guelph, Guelph, ON, Canada N1G 2W1.ORCID https://orcid.org/0000-0002-3343-7722

Ashley NixonDepartment of Animal Biosciences, University of Guelph, Guelph, ON, Canada N1G 2W1.

John P CantDepartment of Animal Biosciences, University of Guelph, Guelph, ON, Canada N1G 2W1.ORCID https://orcid.org/0000-0003-2021-1764

Mark B HurtigDepartment of Clinical Studies, University of Guelph, Guelph, ON, Canada N1G 2W1.ORCID https://orcid.org/0000-0001-7632-937X

University of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the presence of adipose tissue. Furthermore, we hypothesized that this augmented inflammatory response is due, at least in part, to increased exposure of cartilage to adipose tissue-derived c3a. Porcine cartilage explants from market-weight pigs were cultured in the presence or absence of autologous adipose tissue for 96 hours, the final 48 hours of which they were stimulated with LPS (0 or 10

Indexed as

Cell SurvivalInflammationAdipose TissueAnimalsCartilageCartilage, ArticularChondrocytesDinoprostoneFluoresceinsGlycosaminoglycansJointsLipopolysaccharidesNitric OxideNitritesPhenotypeSwinecalcein AMDinoprostoneFluoresceinsGlycosaminoglycansLipopolysaccharidesNitric OxideNitrites

Identifiers

PMID33273890

DOI10.1155/2020/8811001

PMCPMC7676937

OpenAlexW3101415296

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.