ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2020
Prevalence, Risk Factors, and Clinical Characteristics of Lipodystrophy in Insulin-Treated Patients with Diabetes: An Old Problem in a New Era of Modern Insulin.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Prevalence of insulin injection-induced lipohypertrophy detected by ultrasound: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals.Frontiers in endocrinology · 2022Trial
- Feasibility of using a pocket-sized ultrasound imaging device for detecting insulin-derived amyloidosis-like findings in patients with diabetes mellitus: a preliminary study.Fujita medical journal · 2026Article
- Lipodystrophy and associated factors among patients with diabetes receiving insulin therapy: a multicenter study in Ethiopia.Scientific reports · 2026Article
- Article
- Assessment of diabetes knowledge, hypoglycaemia awareness, and adherence to insulin pen usage practices among diabetic patients: a cross-sectional study of determinants and educational needs.BMC public health · 2025Article
- Determinants of Glycemic Control in Thai Adults with Insulin-Treated Type 2 Diabetes Mellitus: A Cross-Sectional Study.Patient preference and adherence · 2025Article
- Enhancing diabetes self-management through the AADE7 self-care behaviors framework: an observational study.Einstein (Sao Paulo, Brazil) · 2025Observational
- Lipodystrophy With an Uncommon Clinical Presentation in a Patient With Insulin-Requiring Type 2 Diabetes Mellitus.Cureus · 2024Article
- Design and Testing of a Smartphone Application for Real-Time Tracking of CSII and CGM Site Rotation Compliance in Patients With Type 1 Diabetes.Journal of diabetes science and technology · 2024Article
- Differences in clinicopathological characteristics between lipohypertrophy and localized insulin-derived amyloidosis: A scoping review.Chronic diseases and translational medicine · 2024Article
- Predicting hypoglycemia in elderly inpatients with type 2 diabetes: the ADOCHBIU model.Frontiers in endocrinology · 2024Article
- Lipohypertrophy and Insulin: An Update From the Diabetes Technology Society.Journal of diabetes science and technology · 2023Article
- Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center.Acta bio-medica : Atenei Parmensis · 2023Article
- Worsening of Glycemic Control in a Patient With Fulminant Type 1 Diabetes Receiving Sensor-Augmented Pump Therapy: A Case of Extensive Localized Lipoatrophy Requiring Attention in Relation to Cannula Insertion Sites.Clinical diabetes : a publication of the American Diabetes Association · 2022Article
- Gender Differences in Prevalence and Clinical Correlates of Lipohypertrophy in Insulin-Exposed Patients with Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Phenolic Preservative Removal from Commercial Insulin Formulations Reduces Tissue Inflammation while Maintaining Euglycemia.ACS pharmacology & translational science · 2021Article
- Lipodystrophy related to insulin injection-often overlooked disorder.Wiener klinische Wochenschrift · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipodystrophy has been reported as a common complication in insulin-treated patients, which could lead to unexplained hypoglycemia and suboptimal glycemic control. This study aimed to determine the prevalence, associated risk factors, and clinical characteristics of insulin-induced lipodystrophy in Thai patients. PATIENTS AND
methodsThis was a cross-sectional study involving insulin-treated patients at Theptarin Hospital, one of the largest diabetes centers in Thailand.
resultsA total of 400 patients were studied (female 53.5%, T2DM 86%, mean age 65.6±15.4 years, duration of diabetes 23.0±10.2 years, median insulin treatment 10 years, usage of insulin analog 72.1%, A1C 7.9±1.6%) . The prevalence of lipohypertrophy (LH) in overall patients was 37.3% (T1DM 46.4% and T2DM 35.8%). The highest prevalence (57.5%) was observed in long-standing (≥10 years) T1DM patients. Multivariate analysis revealed that the duration of insulin use (≥10 years), use of human insulin, and incorrect rotation of injection sites were associated with LH. Patients with LH were found to have 7-times greater risk of unexplained hypoglycemia when compared with patients without LH. Lipoatrophy (LA) was found in only four cases (1.0%). All LA cases had a concurrence palpable area of LH.
conclusionInsulin-induced lipodystrophy is still an overlooked complication in the conundrum of diabetes care. The presence of lipodystrophy was significantly associated with the occurrence of unexplained hypoglycemia. It should be emphasized to recognize this condition by inspecting and palpating insulin injecting sites regularly, and educate patients to avoid the development of lipodystrophy.
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