Evidence map›Paper›PMID 33273832›Full record

ArticleOncoTargets and therapy2020

miR-let-7a-5p Inhibits Invasion and Migration of Hepatoma Cells by Regulating

Ling Liu, Jinfeng Zhao, Ying Peng, Manyi Yang, Lihua Zhang, Xin Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ling LiuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.
Jinfeng ZhaoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.
Ying PengDepartment of International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.
Manyi YangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.
Lihua ZhangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.
Xin JinDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.ORCID 0000-0001-9121-4597
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was performed to investigate the effect of miRNA let-7a-5p on the proliferation, invasion, and migration of human hepatoma cells as well as to determine

methodsWestern blotting and real-time quantitative polymerase chain reaction were used to detect changes in the expression of miRNA let-7a-5p and BZW2 protein and gene, respectively. A luciferase reporter gene assay was used to examine whether

resultsThe luciferase reporter gene assay identified

conclusionmiR-let-7a-5p can inhibit proliferation, invasion, and migration as well as promote apoptosis of hepatoma cells by decreasing

Indexed as

apoptosiscell migrationcell proliferationliver cancer

Identifiers

PMID33273832
PMCPMC7708316
OpenAlexW3107560999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.