Evidence map›Paper›PMID 33273692›Full record

ArticleCommunications biology2020

A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.

Babu Gajendran, Krishnapriya M Varier, Wuling Liu, Chunlin Wang, Klarke M Sample, Eldad Zacksenhaus, Cui Juiwei, LieJun Huang, XiaoJiang Hao, Yaacov Ben-David

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Babu GajendranState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.ORCID 0000-0001-5764-581X
Krishnapriya M VarierDepartment of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600113, India.
Wuling LiuState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.
Chunlin WangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.
Klarke M SampleThe National Health Commission's Key Laboratory of Immunological Pulmonary Disease, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou University, Guiyang, Guizhou, 550002, China.
Eldad ZacksenhausDepartment of Medicine, University of Toronto, Toronto, M5G 2M1, ON, Canada.
Cui JuiweiThe Cancer Center of the First Hospital of Jilin University, Changchun, Jilin, 130021, China.
LieJun HuangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China. huangliejun@126.com.
XiaoJiang HaoState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China. haoxj@mail.kib.ac.cn.
Yaacov Ben-DavidState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China. yaacovbendavid@hotmail.com.
Guiyang Medical University · CNGuizhou University · CNJilin University · CNUniversity Health Network · CAUniversity of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SIN3 repressor complex and the NAD-dependent deacetylase SIRT3 control cell growth, and development as well as malignant transformation. Even then, a little known about cross-talks between these two chromatin modifiers or whether their interaction explored therapeutically. Here we describe the identification of a C

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCo-Repressor ProteinsGene Expression RegulationHistone DeacetylasesLymphoma, T-CellMiceMolecular StructureProtein ConformationRNA-Binding ProteinsSirtuin 3SteroidsAntineoplastic AgentsCo-Repressor ProteinsHistone DeacetylasesRNA-Binding ProteinsSAP18 protein, humanSap18 protein, mouseSap30 protein, mouseSIRT3 protein, humanSirt3 protein, mouseSirtuin 3Steroids

Identifiers

PMID33273692
PMCPMC7713351
OpenAlexW3108409030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.