Evidence map›Paper›PMID 33273683›Full record

ArticleScientific reports2020

Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood.

Andrea Hanel, Antonio Neme, Marjo Malinen, Emmi Hämäläinen, Henna-Riikka Malmberg, Stéphane Etheve, Tomi-Pekka Tuomainen, Jyrki K Virtanen, Igor Bendik, Carsten Carlberg

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Vitamin D is glucoprotective in aging males but not females.The Journal of steroid biochemistry and molecular biology · 2026
    Article
  4. Article
  5. Article
  6. Vitamin D-is the sun enough for us?Nutrition & metabolism · 2025
    Review
  7. Article
  8. Article
  9. EarlyFrontiers in immunology · 2025
    Article
  10. Evaluation of the vitamin D response index in a Saudi cohort.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Andrea HanelSchool of Medicine, Institute of Biomedicine, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.ORCID 0000-0001-6022-4362
Antonio NemeInstitute for Applied Mathematics, Merida Research Unit, National Autonomous University of Mexico, Sierra Papacal, Merida, Yucatan, Mexico.
Marjo MalinenDepartment of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland.
Emmi HämäläinenSchool of Medicine, Institute of Biomedicine, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.
Henna-Riikka MalmbergSchool of Medicine, Institute of Biomedicine, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.
Stéphane EtheveDSM Nutritional Products Inc., R&D Solution Center, Kaiseraugst, Switzerland.
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Igor BendikDSM Nutritional Products Inc., Human Nutrition and Health, Kaiseraugst, Switzerland.
Carsten CarlbergSchool of Medicine, Institute of Biomedicine, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland. carsten.carlberg@uef.fi.ORCID 0000-0003-2633-0684
University of Eastern Finland · FIAutonomous University of Yucatán · MXDSM (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is essential for the function of the immune system. In this study, we treated peripheral blood mononuclear cells (PBMCs) of healthy adults with the biologically active form of vitamin D

Indexed as

AdultCells, CulturedCohort StudiesFemaleGene Expression RegulationGenome, HumanHumansLeukocytes, MononuclearMaleMicronutrientsMiddle AgedVitamin DYoung AdultMicronutrientsVitamin D

Identifiers

PMID33273683
PMCPMC7713372
OpenAlexW3109456608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.