ArticleNature communications2020
Adaptive modulation of brain hemodynamics across stereotyped running episodes.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
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- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
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- Wearable optical coherence tomography angiography probe with extended depth of field.Journal of biomedical optics · 2025Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.Nature communications · 2024Article
- The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice.PLoS biology · 2024Article
- Specific and Nonuniform Brain States during Cold Perception in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks.Journal of neuroscience methods · 2024Article
- Wearable optical coherence tomography angiography probe for freely moving mice.Biomedical optics express · 2023Article
- A sound solution for deep-brain imaging.Nature methods · 2023Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.bioRxiv : the preprint server for biology · 2023Article
- Decoding behavior from global cerebrovascular activity using neural networks.Scientific reports · 2023Article
- Cognition is entangled with metabolism: relevance for resting-state EEG-fMRI.Frontiers in human neuroscience · 2023Article
- Neurovascular coupling: motive unknown.Trends in neurosciences · 2022Review
- [The developments and applications of functional ultrasound imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
During locomotion, theta and gamma rhythms are essential to ensure timely communication between brain structures. However, their metabolic cost and contribution to neuroimaging signals remain elusive. To finely characterize neurovascular interactions during locomotion, we simultaneously recorded mesoscale brain hemodynamics using functional ultrasound (fUS) and local field potentials (LFP) in numerous brain structures of freely-running overtrained rats. Locomotion events were reliably followed by a surge in blood flow in a sequence involving the retrosplenial cortex, dorsal thalamus, dentate gyrus and CA regions successively, with delays ranging from 0.8 to 1.6 seconds after peak speed. Conversely, primary motor cortex was suppressed and subsequently recruited during reward uptake. Surprisingly, brain hemodynamics were strongly modulated across trials within the same recording session; cortical blood flow sharply decreased after 10-20 runs, while hippocampal responses strongly and linearly increased, particularly in the CA regions. This effect occurred while running speed and theta activity remained constant and was accompanied by an increase in the power of hippocampal, but not cortical, high-frequency oscillations (100-150 Hz). Our findings reveal distinct vascular subnetworks modulated across fast and slow timescales and suggest strong hemodynamic adaptation, despite the repetition of a stereotyped behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.