ArticleScience (New York, N.Y.)2020
The N-glycome regulates the endothelial-to-hematopoietic transition.
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Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Large glycomics datasets as a tool to understand the function of glycans.Nature chemical biology · 2026Review
- Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates.EMBO reports · 2026Article
- Emergence of endothelial subtypes and role of cell cycle control in arterial-venous specification during embryonic vascular development.Cell reports · 2025Article
- Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions.Nature communications · 2025Article
- An ancient and essential miRNA family controls cellular interaction pathways inScience advances · 2025Article
- Development and application of GlycanDIA workflow for glycomic analysis.Nature communications · 2025Article
- Article
- Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy.Nature communications · 2024Article
- Akt is a mediator of artery specification during zebrafish development.Development (Cambridge, England) · 2024Article
- Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models.Nature communications · 2023Article
- Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models.Emerging topics in life sciences · 2023Review
- Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data ofBiology · 2023Review
- Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium.Nature cell biology · 2023Article
- Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium.Nature cell biology · 2023Article
- MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis.Developmental cell · 2023Article
- Hematopoietic heterogeneity starts at the hemogenic endothelium.Cell research · 2023Article
- Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity.Cell research · 2023Article
- Review
- ADAM10-a "multitasker" in sepsis: focus on its posttranslational target.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- De Novo Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells for Cellular Therapy.Cells · 2023Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Dionna M KasperYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-3964-6680
Jared HintzenYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Yinyu WuYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-4105-3921
Joey J GhersiYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Hanna K MandlYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Kevin E SalinasYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-5838-8672
William ArmeroYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.ORCID 0000-0002-7373-6348
Zhiheng HeYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Ying ShengDepartment of Chemistry, University of California, Davis, CA 95616, USA.ORCID 0000-0002-6002-9783
Yixuan XieDepartment of Chemistry, University of California, Davis, CA 95616, USA.ORCID 0000-0002-8512-6053
Daniel W HeindelBiomedical Chemistry Institute, Department of Chemistry, New York University, New York, NY 10003, USA.ORCID 0000-0002-4760-4501
Eon Joo ParkVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA.
William C SessaVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-5759-1938
Lara K MahalBiomedical Chemistry Institute, Department of Chemistry, New York University, New York, NY 10003, USA.ORCID 0000-0003-4791-8524
Carlito LebrillaDepartment of Chemistry, University of California, Davis, CA 95616, USA.ORCID 0000-0001-7190-5323
Karen K HirschiYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA. stefania.nicoli@yale.edu kkh4yy@virginia.edu.ORCID 0000-0001-7116-0130
Stefania NicoliYale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA. stefania.nicoli@yale.edu kkh4yy@virginia.edu.ORCID 0000-0001-7055-340X
Yale University · USUniversity of California, Davis · USNew York University · USUniversity of Alberta · CA
Funding
Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7MIMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1MThe incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3MmiR-223 regulates endothelial to hematopoietic transitionR01DK118728 · NIDDK · YALE UNIVERSITY · PI HIRSCHI, KAREN KEMPER, NICOLI, STEFANIA · 2020 to 2023
$2.9MSpecification of Hemogenic Endothelial CellsR01HL128064 · NHLBI · YALE UNIVERSITY · PI DICKINSON, MARY E, HIRSCHI, KAREN KEMPER · 2015 to 2018
$2.6MEndothelial Cell Cycle State and Cell FateR01HL146056 · NHLBI · UNIVERSITY OF VIRGINIA · PI HIRSCHI, KAREN KEMPER · 2019 to 2022
$2.1MIntegrating miR-107 into signaling pathways that coordinate neurogenesis and brain vascular permeabilityR01HL130246 · NHLBI · YALE UNIVERSITY · PI NICOLI, STEFANIA · 2016 to 2020
$2.1MDefining miR-223-dependent mechanisms regulating hematopoietic stem cell production from endotheliumK99HL141687 · NHLBI · YALE UNIVERSITY · PI KASPER, DIONNA · 2018 to 2019
$205kInvestigating the Role for Mir-223 in Hematopoietic Stem Cell EmergenceF32HL132475 · NHLBI · YALE UNIVERSITY · PI KASPER, DIONNA · 2016 to 2018
$128kmiR-223 regulates endothelial to hematopoietic transitionR56DK118728 · NIDDK · YALE UNIVERSITY · PI HIRSCHI, KAREN KEMPER, NICOLI, STEFANIA · 2018 to 2018
$100kNHLBI NIH HHS F32 HL132475NHLBI NIH HHS K99 HL141687NHLBI NIH HHS R01 HL128064NHLBI NIH HHS R01 HL130246NHLBI NIH HHS R01 HL146056NHLBI NIH HHS T32 HL007974NIDDK NIH HHS R01 DK118728NIDDK NIH HHS R56 DK118728NIDDK NIH HHS U54 DK106857NIGMS NIH HHS R01 GM049077
Abstract
Definitive hematopoietic stem and progenitor cells (HSPCs) arise from the transdifferentiation of hemogenic endothelial cells (hemECs). The mechanisms of this endothelial-to-hematopoietic transition (EHT) are poorly understood. We show that microRNA-223 (miR-223)-mediated regulation of N-glycan biosynthesis in endothelial cells (ECs) regulates EHT. miR-223 is enriched in hemECs and in oligopotent nascent HSPCs. miR-223 restricts the EHT of lymphoid-myeloid lineages by suppressing the mannosyltransferase
Indexed as
Cell TransdifferentiationADAM10 ProteinAnimalsAnimals, Genetically Modifiedbeta-Galactoside alpha-2,3-SialyltransferaseCell LineageEndothelial CellsGenes, ReporterGlycomicsGlycoproteinsGlycosylationHematopoietic Stem CellsMannosyltransferasesMicroRNAsPolysaccharidesSialyltransferasesADAM10 Proteinbeta-Galactoside alpha-2,3-SialyltransferaseGlycoproteinsMannosyltransferasesmicroRNA-223, zebrafishMicroRNAsPolysaccharidesSialyltransferases
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