Evidence map›Paper›PMID 33273074›Full record

ArticleScience (New York, N.Y.)2020

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.

Raoul Martin, Tiancong Qi, Haibo Zhang, Furong Liu, Miles King, Claire Toth, Eva Nogales, Brian J Staskawicz

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

219 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026
    Review
  8. Article
  9. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  10. CabioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. TIR-like NADases act in bacterial immunity and the RNA vault.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. An Auto-Activated NLR-Protein OsRGA3Plant biotechnology journal · 2026
    Article
  16. Review
  17. Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026
    Review
  18. Fine mapping and functional verification of the Cf-19 gene controlling leaf mold disease resistance in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Article
  19. Article
  20. Review

159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Raoul MartinBiophysics Graduate Group, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-4507-915X
Tiancong QiCenter for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-1971-2481
Haibo ZhangCenter for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-4432-9580
Furong LiuInnovative Genomics Institute, University of California, Berkeley, CA 94720 USA.ORCID 0000-0001-9753-2449
Miles KingInnovative Genomics Institute, University of California, Berkeley, CA 94720 USA.
Claire TothDepartment of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA.ORCID 0000-0003-1811-4180
Eva NogalesQB3, University of California, Berkeley, CA 94720, USA. enogales@lbl.gov stask@berkeley.edu.ORCID 0000-0001-9816-3681
Brian J StaskawiczDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720 USA. enogales@lbl.gov stask@berkeley.edu.ORCID 0000-0002-9711-3962

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008295 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HURLEY, JAMES H, WEMMER, DAVID E · 1989 to 2022
$8.1M
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM008295
6 · The paper itself

Abstract

Plants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an immune response. How effector sensing triggers NLR activation remains poorly understood. Here we describe the 3.8-angstrom-resolution cryo-electron microscopy structure of the activated ROQ1 (recognition of XopQ 1), an NLR native to

Indexed as

Host-Pathogen InteractionsBacterial ProteinsCryoelectron MicroscopyDisease ResistanceNicotianaNLR ProteinsPlant DiseasesPlant ProteinsProtein BindingProtein DomainsProtein MultimerizationXanthomonasBacterial ProteinsNLR ProteinsPlant Proteins

Identifiers

PMID33273074
PMCPMC7995448

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.