Evidence map›Paper›PMID 33272981›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

A Performance Comparison of Commonly Used Assays to Detect RET Fusions.

Soo-Ryum Yang, Umut Aypar, Ezra Y Rosen, Douglas A Mata, Ryma Benayed, Kerry Mullaney, Gowtham Jayakumaran, Yanming Zhang, Denise Frosina, Alexander Drilon and 4 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 79 citations in OpenAlex.

  1. Cancer biology & therapy · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. AccurateInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Round-Robin Comparison of RET Rearrangement Detection in ctDNA: A Novel Method for Limited Clinical Samples.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Precision therapy in metastatic breast cancer: the current landscape of molecular alteration-based therapies.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Soo-Ryum YangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. yangs2@mskcc.org.ORCID 0000-0002-1051-502X
Umut AyparDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-2226-6163
Ezra Y RosenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Douglas A MataDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ryma BenayedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-3754-0321
Kerry MullaneyDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Gowtham JayakumaranDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Yanming ZhangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Denise FrosinaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Alexander DrilonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-6806-9061
Marc LadanyiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Achim A JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Natasha RekhtmanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-5801-3144
Jaclyn F HechtmanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeSelpercatinib and pralsetinib induce deep and durable responses in patients with advanced EXPERIMENTAL

designTumors underwent DNA-based next-generation sequencing (NGS) with reflex to RNA-based NGS if no mitogenic driver or if a

resultsA total of 171 of 41,869 patients with DNA NGS harbored

conclusionsAlthough DNA sequencing has high sensitivity and specificity, RNA sequencing of

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkers, TumorChildChild, PreschoolFemaleFollow-Up StudiesHigh-Throughput Nucleotide SequencingHumansInfantIn Situ Hybridization, FluorescenceMaleMiddle AgedNeoplasmsBiomarkers, TumorOncogene Proteins, FusionProto-Oncogene Proteins c-retRET protein, human

Identifiers

PMID33272981
PMCPMC8285056
OpenAlexW3106826384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.